Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A.
Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A.
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DOI：
10.1016/j.neulet.2012.04.072
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发表时间：
2012-06-27
影响因子：
2.5
通讯作者：
Kling, Mitchel A.
中科院分区：
文献类型：
--
作者：
Gold, Philip W.;Pavlatou, Maria G.;Carlson, Paul J.;Luckenbaugh, David A.;Costello, Rene;Bonne, Omer;Csako, Gyorgy;Drevets, Wayne C.;Remaley, Alan T.;Charney, Dennis S.;Neumeister, Alexander;Kling, Mitchel A.
有证据表明，重度抑郁症患者存在促炎状态，急性期蛋白和炎症介质（如白细胞介素-6和肿瘤坏死因子-α）水平持续升高。我们在这里报告的免疫球蛋白A（伊加）在无药物治疗的抑郁症缓解状态（ruMDD）患者的血清水平的研究。选择性伊加缺乏是免疫球蛋白异常的最常见形式，并且通常与促炎和自身免疫现象的发生率高于预期相关。我们在平衡、随机、盲态条件下，在假耗竭和色氨酸（TrpD）耗竭后0（治疗前）、7和24小时，测量了28例ruMDD患者和27例健康受试者（对照）的血清IgG、IgM和伊加，其中色氨酸耗竭至少间隔8天。免疫球蛋白通过自动免疫荧光测定法测量。通过重复测量ANOVA分析数据，其中诊断作为固定效应，药物（TrpD与假手术）和时间作为重复测量因素。在检查的所有时间点，ruMDD患者的血清伊加始终低于对照组（对于诊断的主要影响，p< 0.04）。血清IgG和IgM水平没有显示出显着差异的诊断。无药物治疗的抑郁症患者在缓解状态下血清伊加水平显着降低，多次测量。鉴于伊加具有许多免疫调节和抗炎作用，这一发现支持了重性抑郁症代表促炎状态的概念。
Patents with major depression have evidence of a proinflammatory state with consistent elevations in acute phase proteins and in the levels of inflammatory mediators such as Interleukin-6 and Tumor necrosis factor-α. We report here a study of the serum levels of Immunoglobulin A (IgA) in medication-free patients with major depression in the remitted state (ruMDD). Selective IgA deficiency is the most common form of immunoglobulin abnormality, and is often associated with a higher than expected incidence of proinflammatory and autoimmune phenomena. We measured serum IgG, IgM, and IgA in 28 ruMDD patients and 27 healthy subjects (Ctrl) at 0 (pretreatment), 7, and 24 hours following sham depletion and tryptophan (TrpD) depletion conducted at least 8 days apart under balanced, randomized, blinded conditions. Immunoglobulins were measured by automated immunonephelometry. Data were analyzed by repeated measures ANOVA with diagnosis as a fixed effect and drug (TrpD vs. sham), and time as repeated measures factors. Serum IgA was consistently lower in ruMDD patients vs. Ctrl at all time points examined (p< 0.04 for main effect of diagnosis). Serum IgG and IgM levels did not show significant differences by diagnosis. Medication-free patients with major depression in the remitted state have a significant reduction in serum IgA levels measured on multiple occasions. In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state.
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影响因子：
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