Copy number variations of obesity relevant loci associated with body mass index in young Chinese.
Copy number variations of obesity relevant loci associated with body mass index in young Chinese.
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中国年轻人体重指数相关肥胖相关位点的拷贝数变异。
DOI：
10.1016/j.gene.2012.12.081
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发表时间：
2013-03
期刊：
影响因子：
3.5
通讯作者：
Ning, Guang
中科院分区：
文献类型：
--
作者：
Sun, Chen;Cao, Min;Shi, Juan;Li, Lijuan;Miao, Lin;Hong, Jie;Cui, Bin;Ning, Guang
肥胖症是人类最复杂的疾病之一，受到广泛关注和研究。最近，拷贝数变异（CNVs）成为影响各种人类疾病的另一个重要遗传标记。为了阐明肥胖与CNVs之间的关系，本研究选择了肥胖相关的候选CNVs，并分析了它们与体重指数（BMI）的关系。结果显示，在中国东部青年人群中，8q24.3位点的CNV频率在肥胖组与健康对照组之间存在显著性差异（P=0.0070），而10q11.22和16p11.2等7个候选位点的CNV频率在肥胖组与健康对照组之间无显著性差异（P> 0.05）。8q24.3CNVs与BMI的相关性不显著，而5p15.33拷贝数与BMI的相关性显著。这些结果表明，8q24.3 CN增益与肥胖有关，5p15.33也可能有助于肥胖的发病机制，突出了这些CNVs对肥胖风险的重要性，以及提供了新的证据CNVs在常见疾病的病理学。
Obesity is one of the most complex human diseases that are widely concerned and studied. More recently, copy number variations (CNVs) emerge as another important genetic marker to influence various human diseases. To elucidate the relationship between obesity and CNVs, this current study selected obesity-related candidate CNVs and analyzed their association with body mass index (BMI). Results showed that a CNV locus, 8q24.3, was significantly different (P=0.0070) in CNV frequency between the obese and healthy controls in a young eastern Chinese cohort, while no statistical significance was observed in other seven candidate loci including well reported 10q11.22 and 16p11.2 loci. The association of 8q24.3 CNVs with BMI of the subjects only showed marginal significance, while the copy number (CN) of 5p15.33 had a significant correlation with the BMI of the subject. These results suggested that 8q24.3 CN gains was associated with obesity, and 5p15.33 might also contribute to obesity pathogenesis, highlighting the importance of these CNVs for obesity risks, as well as providing new evidence for CNVs in the pathology of common diseases.
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影响因子：
30.8
作者：
Xu, Bin;Roos, J. Louw;Karayiorgou, Maria
通讯作者：
Karayiorgou, Maria
全基因组关联研究表明拷贝数变异可能与中国人群的体重指数有关
影响因子：
3.5
作者：
通讯作者：
--
DOI：
10.1038/oby.2010.323
发表时间：
2011-06
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Chen Y;Liu YJ;Pei YF;Yang TL;Deng FY;Liu XG;Li DY;Deng HW
通讯作者：
Deng HW
影响因子：
3.5
作者：
Liu, Yong-Jun;Liu, Xiao-Gang;Deng, Hong-Wen
通讯作者：
Deng, Hong-Wen
影响因子：
30.8
作者：
Erwin G. Van Meir;P. Polverini;V. Chazin;H. Huang;N. Tribolet;W. Cavenee
通讯作者：
Erwin G. Van Meir;P. Polverini;V. Chazin;H. Huang;N. Tribolet;W. Cavenee