COVID-19 and Candida duobushaemulonii superinfection: A case report.
COVID-19 and Candida duobushaemulonii superinfection: A case report.
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DOI：
10.1016/j.mycmed.2021.101168
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发表时间：
2021-09
影响因子：
3.6
通讯作者：
Bizri AR
中科院分区：
文献类型：
--
作者：
Awada B;Alam W;Chalfoun M;Araj G;Bizri AR
由于重症监护病房入住、机械通气和广谱抗生素等多种易感因素，COVID-19危重患者院内细菌和真菌感染的风险很高。关于COVID-19患者中多重耐药（MDR）念珠菌种类的数据很少，而关于双重念珠菌重复感染的数据则不存在。1例34岁男性患者因COVID-19感染而出现急性呼吸窘迫综合征（ARDS），经多疗程抗生素治疗和长时间机械通气后出现双假丝酵母菌血症。他死于复发性气胸导致呼吸衰竭和心脏骤停。细菌和真菌感染是危重患者病毒性肺炎的常见并发症。关于COVID-19患者中这些感染的数据研究很少，只有少数病例报告继发感染，大多数没有确定特定的病原体。在COVID-19感染中，住院时间延长、侵入性干预（中心静脉导管、机械通气）和使用广谱抗生素可能会导致细菌和/或真菌重复感染的高风险。改善COVID-19 ICU患者预后的策略应包括早期识别念珠菌血症和适当的抗真菌治疗。
Critically ill COVID-19 patients are at high risk for nosocomial bacterial and fungal infections due to several predisposing factors such as intensive care unit stay, mechanical ventilation, and broad-spectrum antibiotics. Data regarding multidrug resistant (MDR) Candida species in COVID-19 patients is scarce, and nonexistent regarding Candida duobushaemulonii superinfections. A 34-year-old male presented to our institution with acute respiratory distress syndrome (ARDS) due to COVID-19 infection and developed Candida duobushaemulonii fungemia after multiple courses of antibiotics and prolonged mechanical ventilation. He died after recurrent pneumothorax led to respiratory failure and cardiac arrest. Bacterial and fungal infections are common complications of viral pneumonia in critically ill patients. Data regarding these infections in COVID-19 patients has been poorly studied with only a few cases reporting secondary infection, mostly without identifying specific pathogens. Prolonged hospital stays, invasive interventions (central venous catheter, mechanical ventilation), and the use of broad-spectrum antibiotics in COVID-19 infections could carry a high risk of bacterial and/or fungal superinfections. Strategies to improve outcome in COVID-19 ICU patients should include early recognition of candidemia and appropriate antifungal therapy.
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影响因子：
16.6
作者：
Munoz, Jose F.;Gade, Lalitha;Cuomo, Christina A.
通讯作者：
Cuomo, Christina A.
2020年4月至7月，印度危害病毒病毒病患者的多药念珠菌感染。
影响因子：
11.8
作者：
Chowdhary A;Tarai B;Singh A;Sharma A
通讯作者：
Sharma A
DOI：
10.1016/j.cmi.2020.07.016
发表时间：
2020-12
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Langford BJ;So M;Raybardhan S;Leung V;Westwood D;MacFadden DR;Soucy JR;Daneman N
通讯作者：
Daneman N
影响因子：
4.9
作者：
Ben-Ami, Ronen;Olshtain-Pops, Keren;Giladi, Michael
通讯作者：
Giladi, Michael
DOI：
10.3390/jof6040374
发表时间：
2020-12-17
期刊：
Journal of fungi (Basel, Switzerland)
影响因子：
--
作者：
Jurado-Martín I;Marcos-Arias C;Tamayo E;Guridi A;de Groot PWJ;Quindós G;Eraso E
通讯作者：
Eraso E