Candida duobushaemulonii: An Old But Unreported Pathogen.
Candida duobushaemulonii: An Old But Unreported Pathogen.
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DOI：
10.3390/jof6040374
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发表时间：
2020-12-17
期刊：
影响因子：
--
通讯作者：
Eraso E
中科院分区：
文献类型：
--
作者：
Jurado-Martín I;Marcos-Arias C;Tamayo E;Guridi A;de Groot PWJ;Quindós G;Eraso E
由血念珠菌复合体（血念珠菌和多布沙血念珠菌）及其密切相关的念珠菌耳念珠菌和假血念珠菌引起的念珠菌病正在增加。这些物种通常表现出对抗真菌药物（例如唑类和两性霉素 B 或较少见的棘白菌素）的敏感性降低。然而，传统的表型鉴定方法无法准确地区分这些物种，因此，它们的流行率可能被低估。在这项研究中，使用两种新颖的 PCR 方法重新分析了 150 个可能被错误识别的分离株。我们发现，1996 年被鉴定为中间念珠菌的一个分离株是 C. duobhaemulonii，它是迄今为止描述的该物种最古老的分离株之一。我们还发现该分离株对氟康唑、伊曲康唑和两性霉素 B 的敏感性降低。
Candidiasis caused by species of the Candida haemulonii complex (Candida haemulonii and Candida duobushaemulonii) and closely related species, Candida auris and Candida pseudohaemulonii are increasing. These species often show reduced susceptibility to antifungal drugs, such as azoles and amphotericin B or, less frequently, echinocandins. However, conventional phenotypic identification methods are unable to accurately differentiate these species and, therefore, their prevalence may have been underestimated. In this study, 150 isolates that were probably misidentified were reanalyzed using two novel PCR approaches. We found that one isolate previously identified in 1996 as Candida intermedia was C. duobushaemulonii, being one of the oldest isolates of this species described to date. We also found that this isolate had reduced susceptibility to fluconazole, itraconazole, and amphotericin B.
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影响因子：
9.4
作者：
LEHMANN, PF;WU, LC;AHEARN, DG
通讯作者：
AHEARN, DG
影响因子：
7.1
作者：
Cortegiani A;Misseri G;Fasciana T;Giammanco A;Giarratano A;Chowdhary A
通讯作者：
Chowdhary A
影响因子：
11.8
作者：
de Almeida JN Jr;Assy JG;Levin AS;Del Negro GM;Giudice MC;Tringoni MP;Thomaz DY;Motta AL;Abdala E;Pierroti LC;Strabelli T;Munhoz AL;Rossi F;Benard G
通讯作者：
Benard G
影响因子：
2.8
作者：
Boatto HF;Cavalcanti SD;Del Negro GM;Girão MJ;Francisco EC;Ishida K;Gompertz OF
通讯作者：
Gompertz OF
影响因子：
9.4
作者：
Desnos-Ollivier, Marie;Ragon, Marie;Dromer, Francoise
通讯作者：
Dromer, Francoise