Adding fuel to the fire: The lipid droplet and its associated proteins in cancer progression.
Adding fuel to the fire: The lipid droplet and its associated proteins in cancer progression.
复制标题
火上浇油：脂滴及其相关蛋白质在癌症进展中的作用。
DOI：
10.7150/ijbs.74902
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发表时间：
2022
影响因子：
9.2
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Luo W;Wang H;Ren L;Lu Z;Zheng Q;Ding L;Xie H;Wang R;Yu C;Lin Y;Zhou Z;Xia L;Li G
脂滴（LD）是由磷脂单层和中性脂核组成的细胞器，其表面嵌入或附着蛋白质。直到最近，癌症一直被认为是一种遗传疾病，具有癌基因的异常激活和肿瘤抑制基因的失活，然后才开始认识到其代谢紊乱的性质。近十年来，人们已经认识到癌细胞的几个代谢特征，其中之一是脂滴的积累；因此，人们开始关注ld在肿瘤中的作用。此外，对LD在细胞内稳态中的复杂功能的理解也有了显著的扩展，包括但不限于能量供应、内质网（ER）应激和氧化应激管理，或脂肪毒性减轻。因此，脂滴相关蛋白在很大程度上决定了脂滴的动力学，引起了许多癌症研究人员的兴趣，它们作为癌症诊断生物标志物和治疗靶点的潜力已经被新出现的证据所证实。在这篇综述中，我们系统地总结了LD在癌症中的关键作用，然后重点介绍了对LD生物合成最直接影响的四类脂滴相关蛋白（二酰基甘油酰基转移酶1 （DGAT1）和二酰基甘油酰基转移酶2 (DGAT2)），降解（脂肪甘油三酯脂肪酶（ATGL）），以及LD表面的两个著名蛋白家族（perilipins和细胞死亡诱导DNA片段因子α样效应物（CIDEs））。通过这种方式，我们旨在强调它们在肿瘤进展中的重要作用及其在临床应用中的潜力。
A lipid droplet (LD) is an organelle that consists of a phospholipid monolayer and a neutral lipid core, with proteins embedded in or attached to its surface. Until recently, cancers had long been regarded as genetic disorders with the abnormal activation of oncogenes and inactivation of tumor suppressor genes before their quality of a metabolic disorder began to be recognized. The last decade has witnessed the recognition of several metabolic characteristics of cancer cells, among which one is the accumulation of lipid droplets; therefore, attention has been given to exploring the role of LDs in carcinomas. In addition, there has been a remarkable expansion in understanding the complexity of LD's function in cellular homeostasis, including but not limited to energy supply, endoplasmic reticulum (ER) stress and oxidative stress management, or lipotoxicity alleviation. Thus, lipid droplet-associated proteins, which to a great extent determine the dynamics of a lipid droplet, have attracted the interest of numerous cancer researchers and their potential as cancer diagnostic biomarkers and therapeutic targets has been affirmed by emerging evidence. In this review, we systematically summarize the critical role of LDs in cancer and then focus on four categories of lipid droplet-associated proteins having the most direct influence on LD biosynthesis (diacylglycerol acyltransferase 1 (DGAT1) and diacylglycerol acyltransferase 2 (DGAT2)), degradation (adipose triglyceride lipase (ATGL)), and two renowned protein families on the LD surface (perilipins and cell death-inducing DNA fragmentation factor alpha-like effectors (CIDEs)). In this way, we aim to highlight their important role in tumor progression and their potential in clinical applications.
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影响因子：
5.9
作者：
Balaban S;Shearer RF;Lee LS;van Geldermalsen M;Schreuder M;Shtein HC;Cairns R;Thomas KC;Fazakerley DJ;Grewal T;Holst J;Saunders DN;Hoy AJ
通讯作者：
Hoy AJ
影响因子：
16.1
作者：
Butler LM;Perone Y;Dehairs J;Lupien LE;de Laat V;Talebi A;Loda M;Kinlaw WB;Swinnen JV
通讯作者：
Swinnen JV
影响因子：
3.4
作者：
Chorlay, Aymeric;Thiam, Abdou Rachid
通讯作者：
Thiam, Abdou Rachid
影响因子：
29
作者：
Cheng, Xiang;Geng, Feng;Guo, Deliang
通讯作者：
Guo, Deliang
影响因子：
20.8
作者：
Chen, Li;Zhang, Zhaoyue;Rabinowitz, Joshua D.
通讯作者：
Rabinowitz, Joshua D.