Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention.
Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention.
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DOI：
10.1016/j.addr.2020.07.013
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发表时间：
2020
影响因子：
16.1
通讯作者：
Swinnen JV
中科院分区：
文献类型：
--
作者：
Butler LM;Perone Y;Dehairs J;Lupien LE;de Laat V;Talebi A;Loda M;Kinlaw WB;Swinnen JV
随着研究脂质的有效工具的出现，包括基于质谱的脂质组学，脂质正在成为癌症生物学的核心参与者。脂质作为细胞膜的基本组成部分，作为燃料驱动能量需求过程，并作为信号分子和众多细胞功能的调节剂发挥关键作用。不出所料，癌细胞以及肿瘤微环境中的其他细胞类型利用各种方式获得脂质并广泛地重新连接其代谢，作为由致癌和环境线索驱动的可塑性和环境依赖性代谢重编程的一部分。脂质的命运和组成的变化有助于癌细胞在不断变化的微环境中茁壮成长，支持关键的致癌功能和癌症标志，包括细胞能量学，促进前馈致癌信号传导，抵抗氧化和其他应激，调节细胞间通讯和免疫反应。在脂质代谢改变和致病过程之间的密切联系的支持下，特定的脂质谱正在成为独特的疾病生物标志物，具有诊断、预后和预测潜力。多项临床前研究说明了在癌症中利用脂质代谢的转化前景，并且关键地，已经显示了可以合理靶向的上下文依赖的可操作的弱点，特别是在组合方法中。此外，脂质本身可用作膜破坏剂或用作各种治疗剂的纳米载体的关键组分。随着许多临床前化合物和策略接近临床试验，我们正处于利用迄今为止未被充分认识的癌症标志和肿瘤学家对抗癌症策略中有希望的目标的门口。
With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics, lipids are emerging as central players in cancer biology. Lipids function as essential building blocks for membranes, serve as fuel to drive energy-demanding processes and play a key role as signaling molecules and as regulators of numerous cellular functions. Not unexpectedly, cancer cells, as well as other cell types in the tumor microenvironment, exploit various ways to acquire lipids and extensively rewire their metabolism as part of a plastic and context-dependent metabolic reprogramming that is driven by both oncogenic and environmental cues. The resulting changes in the fate and composition of lipids help cancer cells to thrive in a changing microenvironment by supporting key oncogenic functions and cancer hallmarks, including cellular energetics, promoting feedforward oncogenic signaling, resisting oxidative and other stresses, regulating intercellular communication and immune responses. Supported by the close connection between altered lipid metabolism and the pathogenic process, specific lipid profiles are emerging as unique disease biomarkers, with diagnostic, prognostic and predictive potential. Multiple pre-clinical studies illustrate the translational promise of exploiting lipid metabolism in cancer, and critically, have shown context dependent actionable vulnerabilities that can be rationally targeted, particularly in combinatorial approaches. Moreover, lipids themselves can be used as membrane disrupting agents or as key components of nanocarriers of various therapeutics. With a number of pre-clinical compounds and strategies that are approaching clinical trials, we are at the doorstep of exploiting a hitherto underappreciated hallmark of cancer and promising target in the oncologist’s strategy to combat cancer.
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影响因子：
--
作者：
Al Fayi MS;Gou X;Forootan SS;Al-Jameel W;Bao Z;Rudland PR;Cornford PA;Hussain SA;Ke Y
通讯作者：
Ke Y
影响因子：
19
作者：
Ackerman, Daniel;Simon, M. Celeste
通讯作者：
Simon, M. Celeste
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
DOI：
10.1152/ajpregu.00041.2006
发表时间：
2006-07-01
影响因子：
2.8
作者：
Aja, Susan;Bi, Sheng;McFadden, Jill M.
通讯作者：
McFadden, Jill M.
影响因子：
4.4
作者：
Aryal B;Singh AK;Rotllan N;Price N;Fernández-Hernando C
通讯作者：
Fernández-Hernando C