Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas
Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas
复制标题
通过磁共振成像测量跨膜水流出率作为神经胶质瘤中水通道蛋白4表达的生物标志物
DOI：
10.1038/s41551-022-00960-9
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发表时间：
2022-11
影响因子：
28.1
通讯作者：
Ruiliang Bai
中科院分区：
文献类型：
--
作者：
Yinhang Jia;Shangchen Xu;Guangxu Han;Bao Wang;Zejun Wang;Chuanjin Lan;Peng Zhao;Meng Gao;Yi Zhang;Wenhong Jiang;Biying Qiu;Rui Liu;Yi-Cheng Hsu;Yi Sun;Chong Liu;Yingchao Liu;Ruiliang Bai
水选择性通道蛋白水通道蛋白4（AQP4）有助于胶质瘤的迁移和增殖，并使其对治疗产生抗性。在这里，我们表明，在神经胶质瘤细胞培养，在皮下和原位胶质瘤大鼠，并在胶质瘤患者的肿瘤，跨膜水流出率是一个敏感的生物标志物AQP4的表达，可以通过传统的动态对比增强磁共振成像测量。水流出率与神经胶质瘤增殖的阶段相关，以及与替莫唑胺和AQP4抑制剂TGN 020治疗后啮齿动物和人类神经胶质瘤中肿瘤内和肿瘤间AQP4异质性的变化相关。具有低水流出率的区域含有较高比例的干细胞样慢循环细胞和治疗抗性细胞，这表明水流出率的地图可用于识别对治疗有抗性的胶质瘤。
The water-selective channel protein aquaporin-4 (AQP4) contributes to the migration and proliferation of gliomas, and to their resistance to therapy. Here we show, in glioma cell cultures, in subcutaneous and orthotopic gliomas in rats, and in glioma tumours in patients, that transmembrane water-efflux rate is a sensitive biomarker of AQP4 expression and can be measured via conventional dynamic-contrast-enhanced magnetic resonance imaging. Water-efflux rates correlated with stages of glioma proliferation as well as with changes in the heterogeneity of intra-tumoural and inter-tumoural AQP4 in rodent and human gliomas following treatment with temozolomide and with the AQP4 inhibitor TGN020. Regions with low water-efflux rates contained higher fractions of stem-like slow-cycling cells and therapy-resistant cells, suggesting that maps of water-efflux rates could be used to identify gliomas that are resistant to therapies.
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影响因子：
5.6
作者：
Maugeri R;Schiera G;Di Liegro CM;Fricano A;Iacopino DG;Di Liegro I
通讯作者：
Di Liegro I
影响因子：
82.9
作者：
Klughammer J;Kiesel B;Roetzer T;Fortelny N;Nemc A;Nenning KH;Furtner J;Sheffield NC;Datlinger P;Peter N;Nowosielski M;Augustin M;Mischkulnig M;Ströbel T;Alpar D;Ergüner B;Senekowitsch M;Moser P;Freyschlag CF;Kerschbaumer J;Thomé C;Grams AE;Stockhammer G;Kitzwoegerer M;Oberndorfer S;Marhold F;Weis S;Trenkler J;Buchroithner J;Pichler J;Haybaeck J;Krassnig S;Mahdy Ali K;von Campe G;Payer F;Sherif C;Preiser J;Hauser T;Winkler PA;Kleindienst W;Würtz F;Brandner-Kokalj T;Stultschnig M;Schweiger S;Dieckmann K;Preusser M;Langs G;Baumann B;Knosp E;Widhalm G;Marosi C;Hainfellner JA;Woehrer A;Bock C
通讯作者：
Bock C
影响因子：
5.6
作者：
Ruggieri, Simona;De Giorgis, Michelina;Nico, Beatrice
通讯作者：
Nico, Beatrice
影响因子：
5
作者：
Jovanović M;Dragoj M;Zhukovsky D;Dar'in D;Krasavin M;Pešić M;Podolski-Renić A
通讯作者：
Podolski-Renić A
影响因子：
6.3
作者：
Fukuda, Andrew M.;Adami, Arash;Badaut, Jerome
通讯作者：
Badaut, Jerome