Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis.
Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis.
复制标题
DOI：
10.1016/j.chom.2022.02.004
复制
发表时间：
2022-03-09
影响因子：
30.3
通讯作者：
Gonzalez FJ
中科院分区：
文献类型：
--
作者：
Cai J;Sun L;Gonzalez FJ
炎症性肠病（IBD）和结直肠癌（CRC）是异质肠道疾病，随着人们生活方式的西化，越来越多的人的健康受到威胁。随着各种组学技术的发展，人们发现肠道微生物衍生代谢物在维持肠道内稳态和调节肠道疾病进展方面从代谢和免疫学角度发挥着重要作用。临床宏基因组学和代谢组学研究揭示了微生物胆汁酸（BA）代谢、IBD和CRC进展之间的联系。一些ba衍生的代谢物最近被证明在肠道免疫中发挥作用，为BAs如何影响IBD和CRC的进程提供了新的见解。在这篇综述中，我们讨论了最近关于肠道微生物源性BAs参与肠道免疫、炎症和肿瘤发生的研究，并结合人类组学数据，为IBD和CRC的未来预防和治疗提供前瞻性见解。Cai等人回顾了最近的研究，揭示了肠道微生物来源的胆汁酸与宿主免疫、肠道炎症和肿瘤发生之间的新的机制联系。总结了胆汁酸相关的人类组学数据，并讨论了胆汁酸靶向治疗预防和治疗炎症性肠病和结直肠癌的方法。
Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become Westernized. New insights have been discovered with the development of various omics techniques, revealing that gut microbiota-derived metabolites play important roles in maintaining intestinal homeostasis and modulating the progression of intestinal diseases from both metabolic and immunological perspectives. Clinical metagenomic and metabolomic studies revealed a link between microbial bile acid (BA) metabolism, IBD and CRC progression. Several BA-derived metabolites have recently been demonstrated to play a role in intestinal immunity, providing fresh insights into how BAs affect the course of IBD and CRC. In this review, recent studies on the involvement of gut microbiota-derived BAs in intestinal immunity, inflammation and tumorigenesis are discussed, together with human omics data to provide prospective insights into future prevention and therapy of IBD and CRC. Cai et al. reviews recent studies that reveal novel mechanistic links between gut microbiota-derived bile acids and host immunity, intestinal inflammation, and tumorigenesis. Bile acid-related human omics data are summarized and bile acid-targeted therapeutics for the prevention and treatment of inflammatory bowel disease and colorectal cancer are discussed.
登录
查看更多内容
影响因子：
64.8
作者：
Chen ML;Huang X;Wang H;Hegner C;Liu Y;Shang J;Eliason A;Diao H;Park H;Frey B;Wang G;Mosure SA;Solt LA;Kojetin DJ;Rodriguez-Palacios A;Schady DA;Weaver CT;Pipkin ME;Moore DD;Sundrud MS
通讯作者：
Sundrud MS
DOI：
10.1016/0005-2760(89)90272-5
发表时间：
1989-08-08
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
EDENHARDER, R;PFUTZNER, A;HAMMANN, R
通讯作者：
HAMMANN, R
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
一类重要的微生物胆汁酸的生物合成途径。
影响因子：
14.8
作者：
Devlin AS;Fischbach MA
通讯作者：
Fischbach MA
影响因子：
25.7
作者：
Fouts, Derrick E.;Torralba, Manolito;Nelson, Karen E.;Brenner, David A.;Schnabl, Bernd
通讯作者：
Schnabl, Bernd