Beneficial Effect of Etidronate on Bone Loss After Cessation of Exercise in Postmenopausal Osteoporotic Women
Beneficial Effect of Etidronate on Bone Loss After Cessation of Exercise in Postmenopausal Osteoporotic Women
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依替膦酸对绝经后骨质疏松妇女停止运动后骨质流失的有益作用
DOI：
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发表时间：
2002
影响因子：
3
通讯作者：
S. Ichimura
中科院分区：
文献类型：
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作者：
J. Iwamoto;T. Takeda;S. Ichimura
Iwamoto J，Takeda T，Ichimura S：依替膦酸盐对绝经后骨质疏松妇女停止运动后骨丢失的有益作用。美国物理医学康复杂志2002;81：452-457。目的探讨依替膦酸盐能否预防或恢复绝经后骨质疏松妇女停止运动后的骨丢失。设计35名绝经后乳腺癌妇女进行了研究。锻炼包括每天快走和体操训练。双能X线吸收法测量腰椎骨密度的变化进行了评估。结果1 ~ 2年的运动使骨密度较基线增加。运动一年后停止运动一年，会导致通过运动获得的骨密度损失。预防性依替膦酸盐治疗组从第2年开始的2年周期性依替膦酸盐治疗在停止运动2年期间维持了骨密度，治疗性依替膦酸盐治疗组在停止运动1年后完全恢复了骨密度的损失。结论绝经后骨质疏松症妇女在停止运动后，周期性应用依替膦酸盐治疗，似乎有利于预防或恢复停止运动后的骨丢失。虽然目前的研究样本量很小，但结果可能很有趣，特别是因为它们提出了额外的问题，可能会刺激进一步的研究。
Iwamoto J, Takeda T, Ichimura S: Beneficial effect of etidronate on bone loss after cessation of exercise in postmenopausal osteoporotic women. Am J Phys Med Rehabil 2002;81:452–457. Objectives To determine whether etidronate could prevent or restore bone loss after cessation of exercise in postmenopausal osteoporotic women. Design Thirty-five postmenopausal osteoporotic women were studied. Exercise consisted of daily brisk walking and gymnastic training. The changes in the lumbar bone mineral density measured by dual energy x-ray absorptiometry were assessed. Results One or two years of exercise increased the bone mineral density from the baseline. One year of cessation of exercise after 1 yr of exercise resulted in the loss of the bone mineral density gained through exercise. Two years of cyclical etidronate treatment from year 2 sustained the bone mineral density during 2 yr of cessation of exercise in the preventative etidronate treatment group and completely restored the loss of bone mineral density after 1 yr of cessation of exercise in the therapeutic etidronate treatment group. Conclusions Cyclical etidronate treatment, when exercise is discontinued, seems to be beneficial for the prevention or restoration of bone loss after cessation of exercise in postmenopausal osteoporotic women. Although the present study has a small sample size, the results may be interesting, especially because they raise additional questions that could stimulate further research.
影响因子：
39.2
作者：
DALSKY, GP;STOCKE, KS;BIRGE, SJ
通讯作者：
BIRGE, SJ