The impact of high-resolution structural data on stemming the COVID-19 pandemic.
The impact of high-resolution structural data on stemming the COVID-19 pandemic.
复制标题
高分辨率结构数据对阻止Covid-19的大流行的影响。
DOI：
10.1016/j.coviro.2021.05.005
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发表时间：
2021-08
影响因子：
5.9
通讯作者：
Plemper RK
中科院分区：
文献类型：
--
作者：
Cox RM;Plemper RK
2019冠状病毒病（COVID-19）大流行对人类健康和世界经济造成灾难性影响。科学界的反应是无与伦比的，全球的共同努力导致在比以前不可想象的更短的时间内研制出疫苗。由于这种协调一致的努力，病原体严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）的结构分析以前所未有的速度取得了进展。自大流行开始以来，已经解决了1000多种SARS-CoV-2蛋白质的高分辨率结构，并公开提供。这些结构有助于鉴定许多潜在的可药用靶点，并有助于设计不同的候选疫苗。本文将讨论高分辨率结构对理解SARS-CoV-2生物学的影响，并探讨它们在疫苗和抗病毒药物开发中的作用。
The coronavirus disease 2019 (COVID-19) pandemic has had a catastrophic impact on human health and the world economy. The response of the scientific community was unparalleled, and a combined global effort has resulted in the creation of vaccines in a shorter time frame than previously unimaginable. Reflecting this concerted effort, the structural analysis of the etiological agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has progressed with an unprecedented pace. Since the onset of the pandemic, over 1000 high-resolution structures of a broad range of SARS-CoV-2 proteins have been solved and made publicly available. These structures have aided in the identification of numerous potential druggable targets and have contributed to the design of different vaccine candidates. This opinion article will discuss the impact of high-resolution structures in understanding SARS-CoV-2 biology and explore their role in the development of vaccines and antivirals.
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影响因子：
64.8
作者：
Barnes CO;Jette CA;Abernathy ME;Dam KA;Esswein SR;Gristick HB;Malyutin AG;Sharaf NG;Huey-Tubman KE;Lee YE;Robbiani DF;Nussenzweig MC;West AP Jr;Bjorkman PJ
通讯作者：
Bjorkman PJ
影响因子：
16
作者：
Bravo JPK;Dangerfield TL;Taylor DW;Johnson KA
通讯作者：
Johnson KA
影响因子：
3.7
作者：
Bose, Sayantan;Jardetzky, Theodore S.;Lamb, Robert A.
通讯作者：
Lamb, Robert A.
影响因子：
16.6
作者：
Douangamath A;Fearon D;Gehrtz P;Krojer T;Lukacik P;Owen CD;Resnick E;Strain-Damerell C;Aimon A;Ábrányi-Balogh P;Brandão-Neto J;Carbery A;Davison G;Dias A;Downes TD;Dunnett L;Fairhead M;Firth JD;Jones SP;Keeley A;Keserü GM;Klein HF;Martin MP;Noble MEM;O'Brien P;Powell A;Reddi RN;Skyner R;Snee M;Waring MJ;Wild C;London N;von Delft F;Walsh MA
通讯作者：
Walsh MA
影响因子：
5.2
作者：
Delang, Leen;Segura Guerrero, Nidya;Leyssen, Pieter
通讯作者：
Leyssen, Pieter