Significance of Skin Barrier Dysfunction in Atopic Dermatitis.
Significance of Skin Barrier Dysfunction in Atopic Dermatitis.
复制标题
DOI：
10.4168/aair.2018.10.3.207
复制
发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Leung DYM
中科院分区：
文献类型：
--
作者：
Kim BE;Leung DYM
表皮含有上皮细胞、免疫细胞和微生物，为保护人体皮肤提供了物理和功能屏障。它在防止环境过敏原渗透到人体和应对微生物病原体方面发挥着关键作用。特应性皮炎（AD）是最常见、复杂的慢性炎症性皮肤病。皮肤屏障功能障碍是AD发展的第一步。多种因素，包括免疫失调、聚丝蛋白突变、抗菌肽缺乏和皮肤生态失调，都会导致皮肤屏障缺陷。在 AD 的初始阶段，使用保湿剂治疗可改善皮肤屏障功能并预防 AD 的发展。随着 AD 的进展，需要有效的局部和全身治疗来减少免疫途径激活和一般炎症。靶向微生物组疗法也正在开发中，以纠正与 AD 相关的皮肤生态失调。需要改进 AD 表型和内型的识别和表征，以优化 AD 的精准医学方法。
The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Skin barrier dysfunction is the initial step in the development of AD. Multiple factors, including immune dysregulation, filaggrin mutations, deficiency of antimicrobial peptides, and skin dysbiosis contribute to skin barrier defects. In the initial phase of AD, treatment with moisturizers improves skin barrier function and prevents the development of AD. With the progression of AD, effective topical and systemic therapies are needed to reduce immune pathway activation and general inflammation. Targeted microbiome therapy is also being developed to correct skin dysbiosis associated with AD. Improved identification and characterization of AD phenotypes and endotypes are required to optimize the precision medicine approach to AD.
登录
查看更多内容
影响因子：
7.8
作者：
Furuse, Mikio;Hata, Masaki;Furuse, Kyoko;Yoshida, Yoko;Haratake, Akinori;Sugitani, Yoshinobu;Noda, Tetsuo;Kubo, Akiharu;Tsukita, Shoichiro
通讯作者：
Tsukita, Shoichiro
影响因子：
6.5
作者：
Brauweiler, Anne M.;Goleva, Elena;Leung, Donald Y. M.
通讯作者：
Leung, Donald Y. M.
影响因子：
6.5
作者：
Capone, Kimberly A.;Dowd, Scot E.;Stamatas, Georgios N.;Nikolovski, Janeta
通讯作者：
Nikolovski, Janeta
影响因子：
5.9
作者：
Cardona, Ivan D.;Stillman, Leland;Jain, Neal
通讯作者：
Jain, Neal
DOI：
10.1016/j.jaci.2017.01.011
发表时间：
2017-04
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Brunner PM;Guttman-Yassky E;Leung DY
通讯作者：
Leung DY