Diversity of the human skin microbiome early in life.
Diversity of the human skin microbiome early in life.
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DOI：
10.1038/jid.2011.168
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发表时间：
2011-10
影响因子：
6.5
通讯作者：
Nikolovski, Janeta
中科院分区：
文献类型：
--
作者：
Capone, Kimberly A.;Dowd, Scot E.;Stamatas, Georgios N.;Nikolovski, Janeta
在出生后的几天内，婴儿皮肤的快速表面定植与显著的功能变化相一致。皮肤功能、结构和组成的逐渐成熟在生命的最初几年持续进行。最近的报告揭示了成人皮肤微生物组的地形和时间变化。在这里，我们解决了人类皮肤微生物组如何在生命早期发育的问题。我们发现，皮肤微生物群落的组成在生命的第一年演变，随着年龄的增长，表现出越来越多的多样性。虽然早期定植主要是葡萄球菌，但它们的显著下降有助于在第一年年底增加种群均匀度。与成人的研究结果相似，婴儿皮肤微生物区系的组成似乎具有部位特异性。与成人相比，我们发现厚壁菌门在婴儿皮肤上占主导地位。在这一早期阶段及时和适当地建立健康的皮肤微生物组可能在拒绝接触潜在的传染性微生物方面发挥关键作用，并可能影响微生物组的组成和稳定性，一直延伸到成年期。细菌群落有助于建立皮肤稳态并调节炎症反应。因此，预期早期微生物定殖严重影响皮肤免疫功能的发展。
Within days after birth, rapid surface colonization of infant skin coincides with significant functional changes. Gradual maturation of skin function, structure, and composition continues throughout the first years of life. Recent reports have revealed topographical and temporal variations in the adult skin microbiome. Here we address the question of how the human skin microbiome develops early in life. We show that the composition of cutaneous microbial communities evolves over the first year of life, showing increasing diversity with age. Although early colonization is dominated by Staphylococci, their significant decline contributes to increased population evenness by the end of the first year. Similar to what has been shown in adults, the composition of infant skin microflora appears to be site specific. In contrast to adults, we find that Firmicutes predominate on infant skin. Timely and proper establishment of healthy skin microbiome during this early period might have a pivotal role in denying access to potentially infectious microbes and could affect microbiome composition and stability extending into adulthood. Bacterial communities contribute to the establishment of cutaneous homeostasis and modulate inflammatory responses. Early microbial colonization is therefore expected to critically affect the development of the skin immune function.
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DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
6.1
作者：
Arft, AM;Walker, MD;Wookey, PA
通讯作者：
Wookey, PA
Finegoldia magna（一种厌氧机会致病菌）的完整基因组序列。
DOI：
10.1093/dnares/dsm030
发表时间：
2008-02-29
期刊：
DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子：
--
作者：
Goto T;Yamashita A;Hirakawa H;Matsutani M;Todo K;Ohshima K;Toh H;Miyamoto K;Kuhara S;Hattori M;Shimizu T;Akimoto S
通讯作者：
Akimoto S
影响因子：
3
作者：
Lozupone C;Hamady M;Knight R
通讯作者：
Knight R
影响因子：
3.1
作者：
Bailey, Michael T.;Dowd, Scot E.;Lyte, Mark
通讯作者：
Lyte, Mark