Cellular crosstalk mediating immune evasion in pancreatic cancer microenvironment
Cellular crosstalk mediating immune evasion in pancreatic cancer microenvironment
复制标题
胰腺癌微环境中细胞串扰介导免疫逃避
DOI：
10.21037/apc.2019.06.04
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发表时间：
2019-07
期刊：
影响因子：
--
通讯作者：
Tao Yin
中科院分区：
文献类型：
--
作者：
Gao Chenggang;Qiang Shen;Tao Yin
胰腺导管腺癌(PDAC)是全球第四大常见癌症死亡原因，5年生存率仅为6%。PDAC患者的免疫力下降，相关的免疫逃避是一个研究较少的领域。胰腺癌的微环境是一个错综复杂的网状网络，各种常驻细胞群体在其中密切相互作用。为了了解这些细胞类型所起的作用，我们试图描绘胰腺癌微环境中的各种成分及其在阻碍免疫逃逸中的作用。总而言之，有两层力量影响胰腺癌患者的临床结果。抗肿瘤力量包括CD8+T细胞、NK细胞、M1型巨噬细胞、Th1细胞和树突状细胞(DC)。另一种力量有助于肿瘤细胞免受免疫系统的攻击，包括癌细胞、PSCs、M2型肿瘤相关巨噬细胞(TAMs)、髓系来源的抑制细胞(MDSCs)、Tregs和Th2细胞。打破这两种力量之间平衡的联合治疗可能是一种很有前途的策略，可以让胰腺癌患者受益。
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of death from cancer worldwide, with a poor 5-year survival rate of 6%. Immunity in PDAC patients is diminished and the associated immune evasion is an underinvestigated field. The microenvironment of pancreatic cancer is an intricate mesh-like network in which various resident cell populations are closely interacting. To understand the roles played by these cell types, we attempt to delineate the diversified components in pancreatic cancer microenvironment and their contributions in hampering immune escape. In sum, there are two tiers of force influencing the clinical outcome of patients with pancreatic cancer. The anti-tumor force includes CD8+ T cells, NK cells, M1-type macrophages, Th1 cells, and dendritic cells (DCs). The other force facilitates tumor cells to become free of attacks from immune system, including cancer cells, PSCs, M2-type tumor-associate macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), Tregs, and Th2 cells. Combined therapy to break the balance between the two forces maybe a promising strategy to benefit patients with pancreatic cancer.
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影响因子：
7
作者：
Nakayamada S;Takahashi H;Kanno Y;O'Shea JJ
通讯作者：
O'Shea JJ
影响因子：
64.8
作者：
Kim, Min-Sik;Pinto, Sneha M.;Getnet, Derese;Nirujogi, Raja Sekhar;Manda, Srikanth S.;Chaerkady, Raghothama;Madugundu, Anil K.;Kelkar, Dhanashree S.;Isserlin, Ruth;Jain, Shobhit;Thomas, Joji K.;Muthusamy, Babylakshmi;Leal-Rojas, Pamela;Kumar, Praveen;Sahasrabuddhe, Nandini A.;Balakrishnan, Lavanya;Advani, Jayshree;George, Bijesh;Renuse, Santosh;Selvan, Lakshmi Dhevi N.;Patil, Arun H.;Nanjappa, Vishalakshi;Radhakrishnan, Aneesha;Prasad, Samarjeet;Subbannayya, Tejaswini;Raju, Rajesh;Kumar, Manish;Sreenivasamurthy, Sreelakshmi K.;Marimuthu, Arivusudar;Sathe, Gajanan J.;Chavan, Sandip;Datta, Keshava K.;Subbannayya, Yashwanth;Sahu, Apeksha;Yelamanchi, Soujanya D.;Jayaram, Savita;Rajagopalan, Pavithra;Sharma, Jyoti;Murthy, Krishna R.;Syed, Nazia;Goel, Renu;Khan, Aafaque A.;Ahmad, Sartaj;Dey, Gourav;Mudgal, Keshav;Chatterjee, Aditi;Huang, Tai-Chung;Zhong, Jun;Wu, Xinyan;Shaw, Patrick G.;Freed, Donald;Zahari, Muhammad S.;Mukherjee, Kanchan K.;Shankar, Subramanian;Mahadevan, Anita;Lam, Henry;Mitchell, Christopher J.;Shankar, Susarla Krishna;Satishchandra, Parthasarathy;Schroeder, John T.;Sirdeshmukh, Ravi;Maitra, Anirban;Leach, Steven D.;Drake, Charles G.;Halushka, Marc K.;Prasad, T. S. Keshava;Hruban, Ralph H.;Kerr, Candace L.;Bader, Gary D.;Iacobuzio-Donahue, Christine A.;Gowda, Harsha;Pandey, Akhilesh
通讯作者：
Pandey, Akhilesh
DOI：
10.1073/pnas.1512832112
发表时间：
2015-12-15
影响因子：
11.1
作者：
Demaria, Olivier;De Gassart, Aude;Gilliet, Michel
通讯作者：
Gilliet, Michel
影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
24.5
作者：
Stromnes IM;Brockenbrough JS;Izeradjene K;Carlson MA;Cuevas C;Simmons RM;Greenberg PD;Hingorani SR
通讯作者：
Hingorani SR