Helper T cell diversity and plasticity.
Helper T cell diversity and plasticity.
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DOI：
10.1016/j.coi.2012.01.014
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发表时间：
2012-06
影响因子：
7
通讯作者：
O'Shea JJ
中科院分区：
文献类型：
--
作者：
Nakayamada S;Takahashi H;Kanno Y;O'Shea JJ
CD4+ 辅助 T 细胞具有分化为特殊亚群的能力，在宿主防御和免疫介导的疾病中发挥着关键作用。这些子集响应微生物病原体而获得细胞因子分泌的限制模式和主转录因子的特异性表达。传统上，各种辅助 CD4+ T 细胞亚群被视为灵活性有限的终末分化谱系。然而，在认识到新的子集之后，人们对可塑性的认识也增加了。在这篇综述中，我们重点介绍了与该主题相关的最新进展以及有助于辅助 CD4+ T 细胞分化和可塑性的机制。
CD4+ helper T cells play critical roles for host defense and immune-mediated disease by their ability to differentiate into specialized subsets. These subsets attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to microbial pathogens. Classically, the various helper CD4+ T cell subsets have been viewed as terminally differentiated lineages with limited flexibility. However, following the recognition of new subsets, there is increased recognition of plasticity. In this review, we highlight recent advances that pertain to this topic and the mechanisms that contribute to helper CD4+ T cell differentiation and plasticity.
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