Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer
Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer
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多野照射和硼浓度对硼中子俘获疗法治疗非小细胞肺癌的影响
DOI：
10.18869/acadpub.ijrr.15.1.1
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发表时间：
2017-01
影响因子：
0.6
通讯作者：
Chen D.
中科院分区：
文献类型：
--
作者：
Yu H.;Tang X.;Shu D.;Geng C.;Gong C.;Hang S.;Chen D.
背景：硼中子俘获治疗（BNCT）是一种结合生物靶向和高线性能量转移的放射治疗方法。非小细胞肺癌（NSCLC）是一种潜在的治疗方法。然而，肺部肿瘤的剂量分布并不均匀，这将降低BNCT的治疗效果。为了改善BNCT的剂量分布，需要探索穆尔野照射策略及其效果。材料与方法：在中国混合参考体模中定义了常见的NSCLC模型，皮肤和肿瘤中的硼浓度分别为6 - 18 ppm和30 - 65 ppm。剂量分布计算采用蒙特卡罗方法。采用加速器中子源（Neuboron），设计了穆尔场源照射计划，以米泽剂量分布。结果：在单场照射下，由于皮肤剂量不可能达到其剂量限值，BNCT是不可行的。两野和三野照射下，肿瘤剂量均匀性提高，危及器官最大剂量降低。当皮肤中硼浓度在6-18 ppm之间时，BNCT是可行的，肿瘤中硼浓度在双野照射时可达5760 ppm，三野照射时可达41-45 ppm。结论：采用穆尔野照射计划可改善非小细胞肺癌BNCT的剂量分布，提高BNCT的可行性。获得了符合BNCT治疗要求的10 ~（10）B的理论分布，为今后穆尔多野照射BNCT治疗NSCLC提供参考。
Background: Boron neutron capture therapy (BNCT) is a radiotherapy that combines biological targe ng and high linear energy transfer. A poten al therapeu c approach for non-small cell lung cancer (NSCLC) is considered. However, dose in lung tumor is not homogeneous, and it will reduce the effect of BNCT treatment. In order to improve the dose distribu on of BNCT, the mul -field irradia on strategy and its effects need to be explored. Materials and Methods: Common NSCLC model was defined in Chinese hybrid reference phantom and the boron concentra on in skin and tumor varied from 6 to 18 ppm and from 30 to 65 ppm, respec vely. Monte Carlo method for dose distribu on calcula on was used. Accelerator-based neutron source called “Neuboron source” was used and mul -field source irradia on plans were designed to op mize the dose distribu on. Results: Under onefield irradia on, it was not feasible to perform BNCT, because the skin dose is unlikely to meet its dose limit. Under twoand three-field irradia on, the uniformity of tumor dose was improved and the maximum dose to organs at risk (OARs) decreased. If boron concentra on in skin was between 6-18 ppm, BNCT was feasible with the boron concentra on in tumor reaching about 5760 ppm for two-field irradia on and 41-45 ppm for three-field irradia on, respec vely. Conclusion: The mul -field irradia on plan could improve the dose distribu on and the feasibility of BNCT for NSCLC. Theore cal distribu ons of Boron-10 were obtained to meet the treatable requirement of BNCT, which could provide a reference for NSCLC using BNCT in future mul ple-field irradia on.
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影响因子：
--
作者：
J. Fantidis;A. Antoniadis
通讯作者：
J. Fantidis;A. Antoniadis
影响因子：
3
作者：
T. Guitton;A. Kinaci;D. Ring
通讯作者：
T. Guitton;A. Kinaci;D. Ring
DOI：
--
发表时间：
2013
期刊：
Journal of the National Comprehensive Cancer Network : JNCCN
影响因子：
--
作者：
D. Ettinger;W. Akerley;H. Borghaei;Andrew C. Chang;R. Cheney;L. Chirieac;T. D’amico;T. Demmy;
通讯作者：
D. Ettinger;W. Akerley;H. Borghaei;Andrew C. Chang;R. Cheney;L. Chirieac;T. D’amico;T. Demmy;
影响因子：
3.8
作者：
Goorley, JT;Kiger, WS;Zamenhof, RG
通讯作者：
Zamenhof, RG
DOI：
10.1007/s11431-014-5480-x
发表时间：
2014-02
期刊：
Science China Technological Sciences
影响因子：
--
作者：
C. Geng;Xiaobin Tang;Xiaoxiao Hou;Diyun Shu;Da Chen
通讯作者：
C. Geng;Xiaobin Tang;Xiaoxiao Hou;Diyun Shu;Da Chen