Spondyloarthropathy as an Old World phenomenon.

Spondyloarthropathy as an Old World phenomenon.
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脊柱关节病是旧世界的一种现象。

DOI:
10.1016/0049-0172(92)90024-8
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发表时间:
1992
影响因子:
5
通讯作者:
Woods,RJ
Woods,RJ
中科院分区:
医学2区
文献类型:
--
作者:
Rothschild,BM;Woods,RJ

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The presence of spine and sacroiliac involvement and the nature and distribution of erosive lesions allowed definitive diagnosis of spondyloarthropathy in the great apes (GorillaandPan[chimpanzee]), the lesser ape (Hylobates), and Old World monkeys (Theropithecus, Papio, Cercopithecus, Macaca, Colobus, Presbytis, andErythrocebus). Analysis of lesional character, distribution, radiological appearance, and sex ratios showed a picture indistinguishable from human spondyloarthropathy. This contrasts with orangutans (Pongo), who lack reactive bone or sacroiliac involvement. A different pathophysiology, as yet undefined, is implied for their erosive arthritis. Limited individual susceptibility to spondyloarthropathy in humans (1% to 4%), Old World monkeys (2.4%), and lesser apes (2.4%) contrasts with the high frequency of disease in the great apes (20% to 28%). The wide geographic distribution of this phenomenon suggests an African and perhaps Asian “panendemic.” This natural disease state provides a unique model for in-depth analysis of the contribution of genetic and environmental factors to disease pathophysiology.
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DOI: --
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期刊:
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