Bällchen participates in proliferation control and prevents the differentiation of Drosophila melanogaster neuronal stem cells
Bällchen participates in proliferation control and prevents the differentiation of Drosophila melanogaster neuronal stem cells
复制标题
Bällchen 参与增殖控制并阻止果蝇神经元干细胞的分化
作者：
T. Yakulov;Ufuk Günesdogan;H. Jäckle;A. Herzig
干细胞不断产生分化的子细胞，对组织稳态和发育至关重要。它们作为未分化和积极分裂的细胞自我更新的能力受到来自细胞环境、干细胞生态位或细胞分裂过程中细胞命运决定因素的不对称分布的外部信号的控制。在这里，我们报告蛋白激酶Bällchen （BALL）是防止分化以及维持黑胃果蝇神经干细胞（称为神经母细胞）正常增殖所必需的。我们的研究结果表明，球突变体幼虫的大脑体积严重缩小，这是由神经母细胞增殖率降低引起的。此外，球突变型神经母细胞逐渐失去神经母细胞决定因子Miranda和aPKC的表达，提示其过早分化。我们的研究结果表明，BALL是一种新的细胞内在因子，具有调节神经干细胞在发育过程中的增殖能力和分化状态的双重功能。
ABSTRACT Stem cells continuously generate differentiating daughter cells and are essential for tissue homeostasis and development. Their capacity to self-renew as undifferentiated and actively dividing cells is controlled by either external signals from a cellular environment, the stem cell niche, or asymmetric distribution of cell fate determinants during cell division. Here we report that the protein kinase Bällchen (BALL) is required to prevent differentiation as well as to maintain normal proliferation of neuronal stem cells of Drosophila melanogaster, called neuroblasts. Our results show that the brains of ball mutant larvae are severely reduced in size, which is caused by a reduced proliferation rate of the neuroblasts. Moreover, ball mutant neuroblasts gradually lose the expression of the neuroblast determinants Miranda and aPKC, suggesting their premature differentiation. Our results indicate that BALL represents a novel cell intrinsic factor with a dual function regulating the proliferative capacity and the differentiation status of neuronal stem cells during development.
影响因子：
3.3
作者：
Bengtsson, L;Wilson, KL
通讯作者：
Wilson, KL
影响因子：
7.5
作者：
Buttitta, Laura A.;Edgar, Bruce A.
通讯作者：
Edgar, Bruce A.