Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats.
Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats.
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DOI：
10.1016/j.bbr.2012.04.024
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发表时间：
2012-07-15
影响因子：
2.7
通讯作者：
Davidson, T. L.
中科院分区：
文献类型：
--
作者：
Swithers, Susan E.;Laboy, Alycia F.;Clark, Kiely;Cooper, Stephanie;Davidson, T. L.
我们实验室以前的工作已经证明，在大鼠中使用高强度甜味剂的经验导致食物摄入量增加，体重增加和肥胖，沿着热量补偿减少和食物热效应降低。这些变化可能是由于干扰了食物的甜味与食用这些食物的热量或营养结果之间的习得关系而发生的。本实验确定了高强度甜味剂糖精与热量甜味剂葡萄糖的经验是否影响血糖稳态。结果表明，在口服葡萄糖耐量试验期间，先前食用糖精甜味补充剂的动物的血糖水平更高。相比之下，在葡萄糖耐量试验期间，当葡萄糖溶液被直接递送到胃中时，未观察到组间血糖水平的差异。口服葡萄糖耐量反应的差异并不伴随着胰岛素释放的差异;胰岛素释放在先前暴露于糖精的动物和先前暴露于葡萄糖的动物中相似。然而，与葡萄糖暴露动物相比，糖精暴露动物中响应口服葡萄糖耐量试验而非通过灌胃递送的葡萄糖耐量试验的GLP-1释放显著较低。糖精动物中血糖和GLP-1释放的差异是快速和短暂的，表明暴露于干扰甜味和卡路里之间预测关系的高强度甜味剂可能损害能量平衡的一种机制是抑制GLP-1释放，这可能改变葡萄糖稳态并减少饱腹感。
Previous work from our lab has demonstrated that experience with high-intensity sweeteners in rats leads to increased food intake, body weight gain and adiposity, along with diminished caloric compensation and decreased thermic effect of food. These changes may occur as a result of interfering with learned relations between the sweet taste of food and the caloric or nutritive consequences of consuming those foods. The present experiments determined whether experience with the high-intensity sweetener saccharin versus the caloric sweetener glucose affected blood glucose homeostasis. The results demonstrated that during oral glucose tolerance tests, blood glucose levels were more elevated in animals that had previously consumed the saccharin-sweetened supplements. In contrast, during glucose tolerance tests when a glucose solution was delivered directly into the stomach, no differences in blood glucose levels between the groups were observed. Differences in oral glucose tolerance responses were not accompanied by differences in insulin release; insulin release was similar in animals previously exposed to saccharin and those previously exposed to glucose. However, release of GLP-1 in response to an oral glucose tolerance test, but not to glucose tolerance tests delivered by gavage, was significantly lower in saccharin-exposed animals compared to glucose-exposed animals. Differences in both blood glucose and GLP-1 release in saccharin animals were rapid and transient, and suggest that one mechanism by which exposure to high-intensity sweeteners that interfere with a predictive relation between sweet tastes and calories may impair energy balance is by suppressing GLP-1 release, which could alter glucose homeostasis and reduce satiety.
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DOI：
10.1523/jneurosci.3262-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dossat AM;Lilly N;Kay K;Williams DL
通讯作者：
Williams DL
影响因子：
2.9
作者：
Hayes, Matthew R.;De Jonghe, Bart C.;Kanoski, Scott E.
通讯作者：
Kanoski, Scott E.
影响因子：
4.9
作者：
Grill, H. J.;Hayes, M. R.
通讯作者：
Hayes, M. R.
肠道甜味受体在调节人体 GLP-1、PYY 和 CCK 释放中的作用
DOI：
10.1152/ajpendo.00077.2011
发表时间：
2011-08-01
影响因子：
5.1
作者：
Gerspach, A. C.;Steinert, R. E.;Beglinger, C.
通讯作者：
Beglinger, C.
影响因子：
9.8
作者：
de Fonseca, FR;Navarro, M;Blázquez, E
通讯作者：
Blázquez, E