CCAAT enhancer binding protein gamma (C/EBP-γ): An understudied transcription factor.

CCAAT enhancer binding protein gamma (C/EBP-γ): An understudied transcription factor.
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CCAAT增强子结合蛋白伽马(C/EBP-γ):研究的转录因子。

DOI:
10.1016/j.jbior.2022.100861
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发表时间:
2022-05
影响因子:
--
通讯作者:
Stephens, Kimberly E.
Stephens, Kimberly E.
中科院分区:
其他
文献类型:
--
作者:
Renfro, Zachary;White, Bryan E.;Stephens, Kimberly E.

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CCAAT增强子结合蛋白(C/EBP)家族转录因子是广泛生理过程的重要转录介质。C/EBP-γ是最短的C/EBP蛋白,并且缺乏用于募集转录机器的典型激活结构域。尽管C/EBP-γ广泛表达并能够与其他C/EBP蛋白二聚化,但其研究远少于其他C/EBP蛋白,并且据我们所知,还没有关于其功能的综述。本文就C/EBP-γ在细胞增殖、整合应激反应、肿瘤发生、造血和神经系统发育以及代谢等方面的生理作用进行综述,并提出今后的研究方向。
The CCAAT enhancer binding protein (C/EBP) family of transcription factors are important transcriptional mediators of a wide range of physiologic processes. C/EBP-γ is the shortest C/EBP protein and lacks a canonical activation domain for the recruitment of transcriptional machinery. Despite its ubiquitous expression and ability to dimerize with other C/EBP proteins, C/EBP-γ has been studied far less than other C/EBP proteins, and, to our knowledge, no review of its functions has been written. This review seeks to integrate the current knowledge about C/EBP-γ and its physiologic roles, especially in cell proliferation, the integrated stress response, oncogenesis, hematopoietic and nervous system development, and metabolism, as well as to identify areas for future research.
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