Shape and diffusion tensor imaging based integrative analysis of the hippocampus and the amygdala in Alzheimer's disease.
Shape and diffusion tensor imaging based integrative analysis of the hippocampus and the amygdala in Alzheimer's disease.
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基于形状和扩散张量成像的阿尔茨海默病海马和杏仁核综合分析
DOI：
10.1016/j.mri.2016.05.001
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发表时间：
2016-10
影响因子：
2.5
通讯作者：
Miller MI
中科院分区：
文献类型：
--
作者：
Tang X;Qin Y;Wu J;Zhang M;Zhu W;Miller MI
我们使用T1加权图像和扩散张量图像(DTI)综合分析了阿尔茨海默病(AD)患者双侧海马和杏仁核的形态测量和结构完整性。与健康对照组相比，我们在AD患者中发现了显著的海马区和杏仁核体积萎缩。形态分析显示明显的区域性萎缩，其中海马萎缩主要集中在CA1和CA2，杏仁核萎缩主要集中在基底外侧和基底内侧。在所有结构中，AD的结构完整性显示平均分数各向异性(FA)值显著降低，平均迹值增加。除了组间比较外，我们还系统地评估了我们的三种类型的特征(体积、形状和DTI)在区分AD和HCS时的区分能力，包括单独的特征和它们可能的组合。我们发现，当更复杂的形状特征可用时，体积特征是多余的。结合右侧海马的形态和DTI特征，结合支持向量机进行自动分类，得到了最强的分类结果(总体准确率为94.6%，敏感度为95.5%，特异度为93.3%)。
We analyzed, in an integrative fashion, the morphometry and structural integrity of the bilateral hippocampi and amygdalas in Alzheimer's disease (AD) using T1-weighted images and diffusion tensor images (DTIs). We detected significant hippocampal and amygdalar volumetric atrophies in AD relative to healthy controls (HCs). Shape analysis revealed significant region-specific atrophies with the hippocampal atrophy mainly being concentrated on the CA1 and CA2 while the amygdalar atrophy was concentrated on the basolateral and basomedial. In all structures, the structural integrity displayed a significantly decreased mean fractional anisotropy (FA) value and an increased mean trace value in AD. In addition to the inter-group comparisons, we systematically evaluated the discriminative power of our three types of features (volume, shape, and DTI), both individually and in their possible combinations, when differentiating between AD and HCs. We found the volume features to be redundant when the more sophisticated shape features were available. A combination of the shape and DTI features of the right hippocampus, with classification automatically performed by support vector machine, yielded the strongest classification result (overall accuracy, 94.6%; sensitivity, 95.5%; specificity, 93.3%).
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