Medial temporal atrophy in early and late-onset Alzheimer's disease.
Medial temporal atrophy in early and late-onset Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2014.03.009
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发表时间：
2014-09
影响因子：
4.2
通讯作者：
Frisoni GB
中科院分区：
文献类型：
--
作者：
Cavedo E;Pievani M;Boccardi M;Galluzzi S;Bocchetta M;Bonetti M;Thompson PM;Frisoni GB
迟发性和早发性阿尔茨海默病（LOAD，EOAD）影响不同的神经系统，可能是不同的疾病分类实体。最显著的差异是内侧颞叶，在LOAD中受到严重影响，而在EOAD中相对较少。我们评估了18名LOAD和18名EOAD患者以及36名年龄匹配的对照组的杏仁核形态和体积，并探讨了它们与海马体积的关系。应用放射状萎缩标测技术重建杏仁核三维形态，手工测量海马体积。LOAD的萎缩程度大于EOAD：杏仁核为25%比17%，海马为20%比13%。在杏仁核中，LOAD在右侧背侧中央核、外侧核和基底外侧核中显示出比EOAD显著更大的组织损失（20-30%损失，p<0.03），所有已知的都连接到边缘系统区域。在LOAD而不是EOAD中，更大的海马萎缩与左侧背侧中央核和内侧核的杏仁核萎缩相关（r=0.6，p<0.05），也是边缘系统的一部分。这些发现支持了这样一种观点，即边缘系统参与是LOAD的一个突出特征，而不是EOAD。
Late-onset and early-onset Alzhemer’s disease (LOAD, EOAD) affect different neural systems and may be separate nosographic entities. The most striking differences is in the medial temporal lobe, severely affected in LOAD and relatively spared in EOAD. We assessed amygdalar morphology and volume in 18 LOAD and 18 EOAD patients and 36 aged-matched controls, and explored their relationship with hippocampal volume. 3D amygdalar shape was reconstructed with the Radial Atrophy Mapping technique, hippocampal volume was measured using a manual method. Atrophy was greater in LOAD than EOAD: 25% versus 17% in the amygdala and 20% versus 13% in the hippocampus. In the amygdala, LOAD showed significantly greater tissue loss than EOAD in the right dorsal central, lateral, and basolateral nuclei (20-30% loss, p<0.03), all known to be connected to limbic regions. In LOAD but not EOAD, greater hippocampal atrophy was associated with amygdalar atrophy in the left dorsal central and medial nuclei (r=0.6, p<0.05), also part of the limbic system. These findings support the notion that limbic involvement is a prominent feature of LOAD but not EOAD.
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影响因子：
--
作者：
HERZOG, AG;KEMPER, TL
通讯作者：
KEMPER, TL
影响因子：
2.6
作者：
Carlesimo, GA;Marfia, GA;Caltagirone, C
通讯作者：
Caltagirone, C
影响因子：
11
作者：
Frisoni, GB;Testa, C;Laakso, MP
通讯作者：
Laakso, MP
影响因子：
1.7
作者：
Ho, GJ;Hansen, LA;Masliah, E
通讯作者：
Masliah, E
影响因子：
2
作者：
Adolphs, R;Tranel, D;Denburg, N
通讯作者：
Denburg, N