Severe Asthma with Viral Infection can Develop into Eosinophilic Granulomatosis with Polyangiitis.
Severe Asthma with Viral Infection can Develop into Eosinophilic Granulomatosis with Polyangiitis.
复制标题
DOI：
10.2478/rir-2021-0034
复制
发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
哮喘常见于嗜酸性肉芽肿病合并多血管炎（EGPA），哮喘患者EGPA的年发病率远高于普通人群，其触发因素尚不清楚。我们报告一例19岁男性重症哮喘患者，病毒感染后出现嗜酸性粒细胞肺浸润，并发展为临床EGPA。EGPA的诊断由最初的临床表现支持，反复咳嗽和喘息伴红疹，其次是外周嗜酸性粒细胞增多，支气管肺泡灌洗液（BALF）中嗜酸性粒细胞百分比高，以及迁移性肺嗜酸性粒细胞浸润。肺活检显示血管外嗜酸性粒细胞增多。患者对高剂量糖皮质激素和环磷酰胺反应良好，症状和生化指标均有所改善。我们的文献综述发现很少有关于EGPA触发因素的报道，这强调了病毒感染可能是哮喘进展为EGPA的危险因素。
Asthma is common in eosinophilic granulomatosis with polyangiitis (EGPA), and the annual incidence of EGPA in patients with asthma is much higher compared with the general population, and the trigger factor for this is unknown. We report a case of a 19-year-old male with a background of severe asthma who presented with eosinophilic lung infiltration after viral infection, which progressed to clinical EGPA. The diagnosis of EGPA was supported by an initial clinical presentation of recurrent cough and wheezing accompanied by a red rash, followed by peripheral eosinophilia, a high eosinophil percentage in bronchoalveolar lavage fluid (BALF), and migratory pulmonary eosinophilic infiltrates. Lung biopsy showed blood vessels with extravascular eosinophils. The patient responded well to high-dose glucocorticoids and cyclophosphamide, and symptoms and biochemical markers improved. Our literature review identified few reports on the triggers of EGPA, which highlights that viral infection may be a risk factor for asthma that progresses to EGPA.
登录
查看更多内容
影响因子：
--
作者：
MASI, AT;HUNDER, GG;ZVAIFLER, NJ
通讯作者：
ZVAIFLER, NJ
影响因子：
--
作者：
Ribi, Camillo;Cohen, Pascal;Guillevin, Loic
通讯作者：
Guillevin, Loic
影响因子：
5
作者：
GUILLEVIN, L;GUITTARD, T;ROSENTHAL, P
通讯作者：
ROSENTHAL, P
影响因子：
13.2
作者：
Geetha, Duvuru;Jefferson, J. Ashley
通讯作者：
Jefferson, J. Ashley
影响因子：
--
作者：
Jennette, J. C.;Falk, R. J.;Watts, R. A.
通讯作者：
Watts, R. A.