Applications of brain organoids in neurodevelopment and neurological diseases.
Applications of brain organoids in neurodevelopment and neurological diseases.
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脑类器官在神经发育和神经系统疾病中的应用
DOI：
10.1186/s12929-021-00728-4
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发表时间：
2021-04-22
影响因子：
11
通讯作者：
Cai J
中科院分区：
文献类型：
--
作者：
Sun N;Meng X;Liu Y;Song D;Jiang C;Cai J
脑类器官是源自人类胚胎干细胞或多能干细胞的自组织三维组织，并且能够模拟人脑的结构和功能。脑类器官的产生方法丰富且不断改进，现在，体内血管化脑类器官已被大量报道。脑类器官与免疫染色和单细胞测序技术的结合有助于我们了解脑类器官，包括结构组织和细胞类型的多样性。最近的出版物报道，脑类器官可以模拟早期大脑发育的动态时空过程，模拟各种人类大脑疾病，并作为一个有效的临床前平台来测试和指导个性化治疗。本文介绍了脑类器官分化策略的研究现状，总结了目前在医学领域的进展和应用，并讨论了这项有前途的技术面临的挑战和前景。
A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brain organoid generation methods are abundant and continue to improve, and now, an in vivo vascularized brain organoid has been encouragingly reported. The combination of brain organoids with immune-staining and single-cell sequencing technology facilitates our understanding of brain organoids, including the structural organization and the diversity of cell types. Recent publications have reported that brain organoids can mimic the dynamic spatiotemporal process of early brain development, model various human brain disorders, and serve as an effective preclinical platform to test and guide personalized treatment. In this review, we introduce the current state of brain organoid differentiation strategies, summarize current progress and applications in the medical domain, and discuss the challenges and prospects of this promising technology.
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影响因子：
48
作者：
Bian S;Repic M;Guo Z;Kavirayani A;Burkard T;Bagley JA;Krauditsch C;Knoblich JA
通讯作者：
Knoblich JA
影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
Volkow, Nora
影响因子：
158.5
作者：
Driggers, R. W.;Ho, C. -Y.;Vapalahti, O.
通讯作者：
Vapalahti, O.
影响因子：
46.9
作者：
Choi, Bryan D.;Yu, Xiaoling;Maus, Marcela V.
通讯作者：
Maus, Marcela V.
影响因子：
16.2
作者：
Abud EM;Ramirez RN;Martinez ES;Healy LM;Nguyen CHH;Newman SA;Yeromin AV;Scarfone VM;Marsh SE;Fimbres C;Caraway CA;Fote GM;Madany AM;Agrawal A;Kayed R;Gylys KH;Cahalan MD;Cummings BJ;Antel JP;Mortazavi A;Carson MJ;Poon WW;Blurton-Jones M
通讯作者：
Blurton-Jones M