Small Molecule Compounds, A Novel Strategy against Streptococcus mutans.
Small Molecule Compounds, A Novel Strategy against Streptococcus mutans.
复制标题
小分子化合物，对抗变形链球菌的新策略。
DOI：
10.3390/pathogens10121540
复制
发表时间：
2021-11-25
期刊：
影响因子：
--
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Yang S;Zhang J;Yang R;Xu X
龋病是一种常见的口腔传染病，是世界性的公共卫生问题。口腔生物膜是导致龋齿的主要原因。变形链球菌是口腔生物膜内龋病的主要致病因素。除了刷牙和用牙线等机械去除外，局部应用抗菌剂必然有助于控制龋齿，特别是对高危人群。主要的龋病抗菌剂，如洗必泰，都有局限性，包括口感混乱、粘膜酸痛、牙齿变色和破坏口腔微生物平衡。抗菌剂小分子具有良好的抗菌活性、良好的选择性和低毒性，在控制变形链球菌方面具有广阔的应用前景。本文讨论了抗菌剂小分子在控制变形链球菌中的应用，特别是活性化合物的鉴定和开发，以及它们对变形链球菌生长和毒力的作用方式。
Dental caries, as a common oral infectious disease, is a worldwide public health issue. Oral biofilms are the main cause of dental caries. Streptococcus mutans (S. mutans) is well recognized as the major causative factor of dental caries within oral biofilms. In addition to mechanical removal such as tooth brushing and flossing, the topical application of antimicrobial agents is necessarily adjuvant to the control of caries particularly for high-risk populations. The mainstay antimicrobial agents for caries such as chlorhexidine have limitations including taste confusions, mucosal soreness, tooth discoloration, and disruption of an oral microbial equilibrium. Antimicrobial small molecules are promising in the control of S. mutans due to good antimicrobial activity, good selectivity, and low toxicity. In this paper, we discussed the application of antimicrobial small molecules to the control of S. mutans, with a particular focus on the identification and development of active compounds and their modes of action against the growth and virulence of S. mutans.
登录
查看更多内容
影响因子：
2.4
作者：
Green, Brian D;Flatt, Peter R;Bailey, Clifford J
通讯作者：
Bailey, Clifford J
影响因子：
3.8
作者：
Islam, Mohamed Ibrahim Hairul;Arokiyaraj, Selvaraj;Thirugnanasambantham, Krishnaraj
通讯作者：
Thirugnanasambantham, Krishnaraj
影响因子：
6.7
作者：
De, Arpan;Pompilio, Arianna;Vitali, Luca A.
通讯作者：
Vitali, Luca A.
恶唑衍生物抑制变形链球菌生物膜形成、胞外多糖产生和毒力
影响因子：
5
作者：
Chen, Lulu;Ren, Zhi;Li, Yuqing
通讯作者：
Li, Yuqing
影响因子：
3.3
作者：
Chen, Yao;Ju, Yuan;Luo, Youfu
通讯作者：
Luo, Youfu