Species Identity and Size are Associated with Rat Lungworm Infection in Gastropods
Species Identity and Size are Associated with Rat Lungworm Infection in Gastropods
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腹足类动物的物种特性和大小与大鼠肺虫感染相关
DOI：
10.1007/s10393-020-01484-x
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发表时间：
2020
期刊：
影响因子：
2.5
通讯作者：
Cowie, Robert H.
中科院分区：
文献类型：
--
作者：
Medeiros, Matthew C.;Rollins, Randi L.;Echaluse, Ma Vida;Cowie, Robert H.
广州管圆线虫是一种在大鼠和中间宿主之间循环的人畜共患病原体。当人类有意或无意地食用腹足类宿主中的感染性幼虫时，就会发生人畜共患感染，并可能表现为神经管圆线虫病，其特征是嗜酸性脑膜炎，严重的神经功能障碍，甚至死亡。因此，A.广州人兽共患病可能与A. cantonensis幼虫穿越腹足类宿主。我们筛选了来自美国夏威夷欧胡岛14个群落的16种腹足动物，以描述A的分布特征。广管蚜的种类和寄主大小。流行率（感染人口的比例）和感染强度（宿主组织中蠕虫的密度）在腹足类物种之间存在差异。流行率也随腹足类宿主大小而变化，但这种关系在宿主物种之间存在差异。大多数宿主物种表现出积极的增加感染的概率与主机大小，这表明在物种内相对较大的主机有较高的患病率。感染螺体内蠕虫密度与宿主大小无关。这些结果表明，A.广州管圆线虫病感染与人口结构和腹足类群落组成有关，这可能是人类管圆线虫病在不同景观中的风险异质性的基础。
Angiostrongylus cantonensis, the rat lungworm, is an emerging zoonotic pathogen that cycles between definitive rat and intermediate gastropod hosts. Zoonotic infection occurs when humans intentionally or accidentally consume infectious larvae in a gastropod host, and may manifest as neuroangiostrongyliasis, characterized by eosinophilic meningitis, severe neurological impairment, and even death. Thus, the risk ofA. cantonensiszoonoses may be related to the distribution ofA. cantonensislarvae across gastropod hosts. We screened 16 gastropod species from 14 communities on the island of O‘ahu, Hawai‘i, USA, to characterize the distribution ofA. cantonensisamong species and across host size. Prevalence (proportion of the population infected) and infection intensity (density of worms in host tissue) varied among gastropod species. Prevalence also varied with gastropod host size, but this relationship differed among host species. Most host species showed a positive increase in the probability of infection with host size, suggesting that within species relatively larger hosts had higher prevalence. The density of worms in an infected snail was unrelated to host size. These results suggest that variation inA. cantonensisinfection is associated with demographic structure and composition of gastropod communities, which could underlie heterogeneity in the risk of human angiostrongyliasis across landscapes.
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发表时间：
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