Multiplexed Near-Field Optical Trapping Exploiting Anapole States.
Multiplexed Near-Field Optical Trapping Exploiting Anapole States.
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DOI：
10.1021/acsnano.3c03100
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发表时间：
2023-09-12
期刊：
影响因子：
17.1
通讯作者：
Krauss, Thomas F. F.
中科院分区：
文献类型：
--
作者：
Conteduca, Donato;Brunetti, Giuseppe;Barth, Isabel;Quinn, Steven D. D.;Ciminelli, Caterina;Krauss, Thomas F. F.
光镊对生物科学研究产生了重大影响，使生物粒子的研究具有高精度。到目前为止，重点一直是捕获单个颗粒，从细胞到分子水平。然而，生物学本质上是异质的;因此，获得同一种群和物种内的变异对于严格理解生物系统是必要的。光镊已经展示了并行捕获多个目标的能力;然而，当向纳米级移动时，多路复用能力成为一个挑战。在这里，我们通过实验证明了一个共振超颖表面，能够捕获大量的纳米粒子并行，从而打开了大规模的多路复用光捕获领域。超颖表面的晶胞支持一个阿那普尔态，它产生一个强的场增强，用于低功率近场捕获;重要的是，阿那普尔态也比可比的共振模式更容角，这允许它用聚焦光束激发，这是产生所需功率密度和光学力所必需的。我们使用anapole状态来证明在10分钟内捕获100个100 nm聚苯乙烯珠，以及以<250 μW/μm2的中等强度多重捕获脂质囊泡。这一演示将使有关生物系统的异质性，如病毒，细胞外囊泡和其他生物颗粒在纳米级的研究。
Optical tweezers have had a major impact on bioscience research by enabling the study of biological particles with high accuracy. The focus so far has been on trapping individual particles, ranging from the cellular to the molecular level. However, biology is intrinsically heterogeneous; therefore, access to variations within the same population and species is necessary for the rigorous understanding of a biological system. Optical tweezers have demonstrated the ability of trapping multiple targets in parallel; however, the multiplexing capability becomes a challenge when moving toward the nanoscale. Here, we experimentally demonstrate a resonant metasurface that is capable of trapping a high number of nanoparticles in parallel, thereby opening up the field to large-scale multiplexed optical trapping. The unit cell of the metasurface supports an anapole state that generates a strong field enhancement for low-power near-field trapping; importantly, the anapole state is also more angle-tolerant than comparable resonant modes, which allows its excitation with a focused light beam, necessary for generating the required power density and optical forces. We use the anapole state to demonstrate the trapping of 100’s of 100 nm polystyrene beads over a 10 min period, as well as the multiplexed trapping of lipid vesicles with a moderate intensity of <250 μW/μm2. This demonstration will enable studies relating to the heterogeneity of biological systems, such as viruses, extracellular vesicles, and other bioparticles at the nanoscale.
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影响因子：
7
作者：
Conteduca, Donato;Arruda, Guilherme S.;Barth, Isabel;Wang, Yue;Krauss, Thomas F.;Martins, Emiliano R.
通讯作者：
Martins, Emiliano R.
影响因子：
5.7
作者：
Dresser, Lara;Graham, Sarah P.;Miller, Lisa M.;Schaefer, Charley;Conteduca, Donato;Johnson, Steven;Leake, Mark C.;Quinn, Steven D.
通讯作者：
Quinn, Steven D.
影响因子：
4.6
作者：
Brouhard, GJ;Schek, HT;Hunt, AJ
通讯作者：
Hunt, AJ
影响因子：
4.6
作者：
Kenworthy CF;Pjotr Stoevelaar L;Alexander AJ;Gerini G
通讯作者：
Gerini G
影响因子：
38.3
作者：
Berthelot, J.;Acimovic, S. S.;Quidant, R.
通讯作者：
Quidant, R.