Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report.
Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report.
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替莫唑胺和贝伐单抗治疗复发性胶质母细胞瘤的疗效：病例报告。
DOI：
10.3892/ol.2015.2940
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发表时间：
2015-04
期刊：
影响因子：
2.9
通讯作者：
Nakajima S
中科院分区：
文献类型：
--
作者：
Okita Y;Nonaka M;Umehara T;Kanemura Y;Kodama Y;Mano M;Nakajima S
复发性胶质母细胞瘤的软脑膜播散预后差，化疗的姑息疗效最低。替莫唑胺（TMZ）是恶性胶质瘤患者的既定治疗方法，也是脑实质胶质瘤的标准治疗;然而，关于其用于治疗软脑膜播散的报道很少。只有一份报告指出了软脑膜播散对TMZ再激发的放射学反应，表明了潜在的致病作用。虽然贝伐单抗是复发性胶质母细胞瘤的有效疗法，但其对复发性胶质母细胞瘤的软脑膜播散的影响仍不清楚。本研究报告了一例复发性胶质母细胞瘤的软脑膜播散病例，在TMZ和贝伐单抗化疗后观察到短暂的神经和放射学改善。然而，在诊断为软脑膜播散后5个月，患者死于该病。
The prognosis of leptomeningeal dissemination of recurrent glioblastoma is poor, and chemotherapy results in minimal palliative efficacy. Temozolomide (TMZ) is an established therapy for patients with malignant glioma and the standard of care in parenchymal gliomas; however, few reports have been published with regard to its use for the treatment of leptomeningeal dissemination. Only one report has indicated the radiographic response of leptomeningeal dissemination to a TMZ rechallenge, suggesting a potential causative effect. While bevacizumab is an effective therapy for recurrent glioblastoma, its effect on leptomeningeal dissemination of recurrent glioblastoma remains unclear. The present study reports a case of leptomeningeal dissemination of recurrent glioblastoma in which transient neurological and radiological improvement was observed following chemotherapy with TMZ and bevacizumab. However, five months after the diagnosis of leptomeningeal dissemination the patient succumbed to the disease.
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影响因子：
--
作者：
Le Rhun E;Taillibert S;Chamberlain MC
通讯作者：
Chamberlain MC
影响因子：
158.5
作者：
Stupp, R;Mason, WP;Ryan, G
通讯作者：
Ryan, G
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2.4
作者：
Vincent A;Lesser G;Brown D;Vern-Gross T;Metheny-Barlow L;Lawrence J;Chan M
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Chan M
影响因子：
45.3
作者：
Giantonio, Bruce J.;Catalano, Paul J.;Benson, Al B., III
通讯作者：
Benson, Al B., III
影响因子：
158.5
作者：
Sandler, Alan;Gray, Robert;Johnson, David H.
通讯作者：
Johnson, David H.