Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature.
Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature.
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DOI：
10.4048/jbc.2013.16.1.122
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发表时间：
2013-03
影响因子：
2.4
通讯作者：
Chan M
中科院分区：
文献类型：
--
作者：
Vincent A;Lesser G;Brown D;Vern-Gross T;Metheny-Barlow L;Lawrence J;Chan M
大约 5% 的乳腺癌患者在病程中出现软脑膜转移。尽管这些患者有多种治疗选择，但他们的预后通常被认为很差。我们报告一例患者在接受过放疗、放射外科、手术、化疗和生物治疗后出现软脑膜衰竭的病例。该患者在接受贝伐单抗和卡培他滨治疗后出现了长时间的反应。目前文献中有几篇关于使用全身疗法来治疗乳腺癌软脑膜转移的报告，我们对此进行了总结。最后，我们回顾了患者治疗方式的相关效果，并为导致她长时间缓解的机制提供了理由。
Approximately 5% of breast cancer patients develop leptomeningeal metastases over the course of their disease. Though several treatments options are available for these patients, their prognosis is typically considered to be poor. We report a case of leptomeningeal failure after a patient underwent prior radiotherapy, radiosurgery, surgery, chemotherapy, and biologic therapy. This patient experienced a prolonged response after receiving bevacizumab and capecitabine. The literature currently contains several reports regarding the use of systemic therapy to manage leptomeningeal metastases from breast cancer, which we summarize. Finally, we review the relevant effects of the patient's treatment modalities and provide a rationale for the mechanism that led to her prolonged response.
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影响因子：
3.9
作者：
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通讯作者：
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