Small for gestational age and higher birth weight predict childhood obesity in preterm infants.
Small for gestational age and higher birth weight predict childhood obesity in preterm infants.
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DOI：
10.1055/s-0030-1253555
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发表时间：
2010-10
影响因子：
2
通讯作者：
Roberts M
中科院分区：
文献类型：
--
作者：
Gaskins RB;LaGasse LL;Liu J;Shankaran S;Lester BM;Bada HS;Bauer CR;Das A;Higgins RD;Roberts M
我们试图确定早产多物质暴露儿童的小胎龄（SGA）、出生体重和儿童肥胖之间的关系。我们从孕产妇生活方式研究中选取了312名11岁体重指数（BMI；年龄和性别）数据的早产儿（51%为女孩，21.5%为SGA， 46%为产前可卡因，55%为烟草暴露）。多项回归分析了11岁肥胖（OBE）、超重（OW）和SGA、出生体重、第一年生长速度、饮食和身体活动变量之间的关系。总体而言，24%为OBE（年龄BMI≥95百分位数），16.7%为OW （BMI≥85和<95百分位数）。在校正分析中，SGA与OW相关（优势比[OR]=3.4，置信区间[CI] 1.5 ~ 7.5）。较高的出生体重与OBE （OR= 1.8, CI 1.3 ~ 2.4）和OW （OR=1.4, CI 1.1 ~ 2.0）相关。生长速度与OBE （OR=2.7, CI 1.8 ~ 4.0）和OW （OR=1.6, CI 1.1 ~ 2.4）相关。低运动量与OBE （OR=2.1, CI 1.0 - 4.4）和OW （OR=2.1, CI 1.0 - 4.5）相关。物质暴露对肥胖结果没有影响。这些高风险的11岁早产儿中有许多（41%）肥胖/超重。多种生长相关过程可能涉及早产儿的肥胖风险，包括胎儿规划，如SGA效应所示。
We sought to determine the association between small for gestational age (SGA), birth weight, and childhood obesity within preterm polysubstance exposed children. We sampled 312 preterm children with 11-year body mass index (BMI; age- and sex-specific) data from the Maternal Lifestyle Study (51% girls, 21.5% SGA, 46% prenatal cocaine, and 55% tobacco exposed). Multinomial regression analyzed the association between 11-year obesity (OBE) and overweight (OW) and SGA, birth weight, first-year growth velocity, diet, and physical activity variables. Overall, 24% were OBE (BMI for age ≥95th percentile) and 16.7% were OW (BMI ≥85th and <95th percentiles). In adjusted analyses, SGA was associated with OW (odds ratio [OR]=3.4, confidence interval [CI] 1.5 to 7.5). Higher birth weight was associated with OBE (OR = 1.8, CI 1.3 to 2.4) and OW (OR=1.4, CI 1.1 to 2.0). Growth velocity was associated with OBE (OR=2.7, CI 1.8 to 4.0) and OW (OR=1.6, CI 1.1 to 2.4). Low exercise was associated with OBE (OR=2.1, CI 1.0 to 4.4) and OW (OR=2.1, CI 1.0 to 4.5). There was no effect of substance exposure on obesity outcomes. Many (41%) of these high-risk preterm 11-year-olds were obese/overweight. Multiple growth-related processes may be involved in obesity risk for preterm children, including fetal programming as indicated by the SGA effect.
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