Topical Microbicides in HIV Prevention: State of the Promise.
Topical Microbicides in HIV Prevention: State of the Promise.
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DOI：
10.1146/annurev-med-090518-093731
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发表时间：
2020-01-27
影响因子：
10.5
通讯作者：
Hillier SL
中科院分区：
文献类型：
--
作者：
Baeten JM;Hendrix CW;Hillier SL
局部杀微生物剂是具有抗艾滋病毒活性的产品，通常含有直接作用的抗逆转录病毒剂，当用于阴道或直肠时，有可能预防妇女和男子通过性行为感染艾滋病毒。杀微生物剂可以提供对艾滋病毒预防的个人控制，并提供谨慎使用的可能性，这些品质对于性关系中的接受性伴侣（例如女性和跨性别女性和男性）来说可能特别重要，他们加在一起占全球新增艾滋病毒感染的绝大多数。在接受性伴侣的控制下局部应用产品的承诺是在近三十年前提出的;局部杀微生物剂可以预防艾滋病毒的概念证明只是在过去十年中才得到证明。在多项针对高危女性和男性的研究中，已经对杀微生物凝胶、薄膜、插入物和环的强大产品线进行了评估，并对满足人群易用性、可逆性和高安全性需求的产品进行了改进，这是该领域的优先事项。局部杀微生物剂与其他含有抗逆转录病毒的产品一起作为暴露前预防（PrEP），占据了一个独特的利基，提供强大的个人控制，能够轻松启动和停止，并导致对活性抗HIV药物的全身暴露最小化，从而可以最大限度地减少副作用和安全监测的需要。局部杀微生物剂可能会对全球艾滋病毒风险个人和群体的预防需求做出反应，因为口服每日PrEP是不可接受的。杀微生物剂的持续开发为所有人口成功预防艾滋病毒提供了可能性。
Topical microbicides are products with anti-HIV activity, generally incorporating a direct-acting antiretroviral agent, that when applied to the vagina or rectum have the potential to prevent the sexual acquisition of HIV in women and men. Microbicides can provide personal control over HIV prevention and offer the possibility of discreet use, qualities that may be particularly important for receptive partners in sexual relationships such as women and transgender women and men, who together account for the clear majority of new HIV infections worldwide. The promise of a topically-applied product under the control of a receptive partner was proposed nearly three decades ago; proof-of-concept that a topical microbicide can prevent HIV has been demonstrated only within the last decade. A robust pipeline of micobicidal gels, films, inserts and rings has been evaluated in multiple studies among at-risk women and men, and refinement of products that meet population needs of ease of use, reversibility, and high safety is the priority for the field. Topical microbicides join other antiretroviral-containing products that act as pre-exposure prophylaxis (PrEP), occupying a unique niche offering strong personal control, the ability to initiate and discontinue easily, and resulting in minimal systemic exposure to the active anti-HIV agent which may consequently minimize side effects and the need for safety monitoring. Topical microbicides may respond to the prevention desires of individuals and groups at risk for HIV worldwide for whom oral daily PrEP has not been acceptable. Continued microbicide development offers the possibility that all populations may achieve HIV prevention success.
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影响因子：
11.8
作者：
Cranston, Ross D.;Lama, Javier R.;McGowan, Ian
通讯作者：
McGowan, Ian
影响因子：
3.7
作者：
Carballo-Diéguez A;Balán IC;Brown W 3rd;Giguere R;Dolezal C;Leu CS;Marzinke MA;Hendrix CW;Piper JM;Richardson BA;Grossman C;Johnson S;Gomez K;Horn S;Kunjara Na Ayudhya RP;Patterson K;Jacobson C;Bekker LG;Chariyalertsak S;Chitwarakorn A;Gonzales P;Holtz TH;Liu A;Mayer KH;Zorrilla C;Lama J;McGowan I;Cranston RD
通讯作者：
Cranston RD
影响因子：
168.9
作者：
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通讯作者：
Stringer, Jeffrey
影响因子：
4.4
作者：
Carballo-Diéguez A;Giguere R;Dolezal C;Leu CS;Balán IC;Brown W 3rd;Rael C;Richardson BA;Piper JM;Bekker LG;Chariyalertsak S;Chitwarakorn A;Gonzales P;Holtz TH;Liu A;Mayer KH;Zorrilla CD;Lama JR;McGowan I;Cranston RD;MTN-017 Protocol Team
通讯作者：
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影响因子：
6
作者：
Bunge, Katherine E.;Dezzutti, Charlene S.;Hillier, Sharon L.
通讯作者：
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