Preference of Oral Tenofovir Disoproxil Fumarate/Emtricitabine Versus Rectal Tenofovir Reduced-Glycerin 1% Gel Regimens for HIV Prevention Among Cisgender Men and Transgender Women Who Engage in Receptive Anal Intercourse with Men.
Preference of Oral Tenofovir Disoproxil Fumarate/Emtricitabine Versus Rectal Tenofovir Reduced-Glycerin 1% Gel Regimens for HIV Prevention Among Cisgender Men and Transgender Women Who Engage in Receptive Anal Intercourse with Men.
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DOI：
10.1007/s10461-017-1969-1
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发表时间：
2017-12
影响因子：
4.4
通讯作者：
MTN-017 Protocol Team
中科院分区：
文献类型：
--
作者：
Carballo-Diéguez A;Giguere R;Dolezal C;Leu CS;Balán IC;Brown W 3rd;Rael C;Richardson BA;Piper JM;Bekker LG;Chariyalertsak S;Chitwarakorn A;Gonzales P;Holtz TH;Liu A;Mayer KH;Zorrilla CD;Lama JR;McGowan I;Cranston RD;MTN-017 Protocol Team
口服暴露前预防（PrEP）可以预防艾滋病毒传播。然而，有些人可能不喜欢服用系统性每日药物。MTN-017是一项3阶段、2期的杀微生物剂凝胶每日或接受性肛交（RAI）前后直肠给药与每日口服片剂相比的安全性和可接受性研究。在基线时，报告RAI的顺性别男性和变性女性（N=187）在总体喜好、易用性和未来使用可能性方面对每日口服方案的评分高于凝胶方案。在尝试了这三种方法后，28%的人最不喜欢每天口服。凝胶不影响性享受（88%）或改善性享受（7-8%）。大多数伴侣对凝胶使用无反应。凝胶使用的便利性在每日使用的第一次和最后几次之间显著改善。在RAI之前和之后使用直肠凝胶可能构成每日片剂的有吸引力的替代品。产品使用经验可能会增加可接受性。
Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N=187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens. After trying all three, 28% liked daily oral the least. Gel did not affect sexual enjoyment (88%) or improved it (7–8%). Most partners had no reaction to gel use. Ease of gel use improved significantly between the first and the last few times of daily use. A rectal gel used before and after RAI may constitute an attractive alternative to daily tablet. Experience with product use may increase acceptability.
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影响因子：
11.8
作者：
Cranston, Ross D.;Lama, Javier R.;McGowan, Ian
通讯作者：
McGowan, Ian
影响因子：
3.7
作者：
Carballo-Diéguez A;Balán IC;Brown W 3rd;Giguere R;Dolezal C;Leu CS;Marzinke MA;Hendrix CW;Piper JM;Richardson BA;Grossman C;Johnson S;Gomez K;Horn S;Kunjara Na Ayudhya RP;Patterson K;Jacobson C;Bekker LG;Chariyalertsak S;Chitwarakorn A;Gonzales P;Holtz TH;Liu A;Mayer KH;Zorrilla C;Lama J;McGowan I;Cranston RD
通讯作者：
Cranston RD
影响因子：
3.6
作者：
Carballo-Diéguez A;Dolezal C;Bauermeister JA;O'Brien W;Ventuneac A;Mayer K
通讯作者：
Mayer K
影响因子：
4.4
作者：
Grov C;Whitfield TH;Rendina HJ;Ventuneac A;Parsons JT
通讯作者：
Parsons JT
影响因子：
10.5
作者：
Baeten J;Celum C
通讯作者：
Celum C