Early impairment of magnocellular visual pathways mediated by isolated-check visual evoked potentials in primary open-angle glaucoma: a cross-sectional study.
Early impairment of magnocellular visual pathways mediated by isolated-check visual evoked potentials in primary open-angle glaucoma: a cross-sectional study.
复制标题
在原发性开角青光眼中，通过分离的检查视觉诱发电位介导的巨细胞视觉途径的早期损害：一项横断面研究。
DOI：
10.1136/bmjophth-2023-001463
复制
发表时间：
2024-01-17
影响因子：
2.4
通讯作者：
Yang, Yangfan
中科院分区：
文献类型：
--
作者：
Ye, Qiaona;Xu, Kezheng;Chen, Zidong;Liu, Zitian;Fan, Yanmei;Liu, Pingping;Yu, Minbin;Yang, Yangfan
To explore different performances in the magnocellular (MC) and parvocellular (PC) visual pathways in patients with primary open-angle glaucoma (POAG) and to objectively assess impairment in early stage of POAG. This is a cross-sectional study. MC and PC visual pathways were assessed using isolated-check visual evoked potential (ic-VEP). Visual acuity, intraocular pressure, fundus examination, optical coherence tomography and visual field were measured. Signal-to-noise ratios (SNRs), mediated by ic-VEP were recorded. The Spearman’s correlation analysis was used to estimate the relationships between visual functions and structures. Receiver-operating-characteristic (ROC) curves were used to estimate the accuracy in detection of early POAG. 60 participants (30 early POAG eyes and 30 age-matched control subjects) were recruited. MC visual pathway showed a non-linear response function, while PC visual pathway was a linear response function as contrast increased. Early POAG eyes exhibited significantly weaker initial contrast gains and lower maximum responses in the MC visual pathway (p=0.001, p=0.004, respectively). The SNRs at 8% and 32% depths of modulation (DOM) were significantly correlated with temporal-side retinal nerve fibre layer (RNFL) thickness in early POAG in MC-biased stimulation (p=0.017, p=0.020, respectively). The areas under ROC of 16% DOM were 0.780 (sensitivity 80.0%, specificity 63.3%) with the cut-off SNR of 2.07. The MC visual pathway was damaged in the early stage of POAG. The SNRs at 8% and 32% DOM of MC-biased stimulation were significantly correlated with temporal-side RNFL thickness in early POAG, which helped in understanding the mechanisms of visual impairment in the early stage of POAG.
登录
查看更多内容
影响因子：
1.9
作者：
Rudvin, I;Valberg, A;Kilavik, BE
通讯作者：
Kilavik, BE
影响因子：
1.4
作者：
Chen, Xiang-Wu;Zhao, Ying-Xi
通讯作者：
Zhao, Ying-Xi
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R
影响因子：
4.4
作者：
Battista, Josephine;Badcock, David R.;McKendrick, Allison M.
通讯作者：
McKendrick, Allison M.
影响因子：
2.7
作者：
Li, Mu;Ke, Manlin;Chen, Zhiqi
通讯作者：
Chen, Zhiqi