The prophylactic effects of a traditional Japanese medicine, goshajinkigan, on paclitaxel-induced peripheral neuropathy and its mechanism of action.
The prophylactic effects of a traditional Japanese medicine, goshajinkigan, on paclitaxel-induced peripheral neuropathy and its mechanism of action.
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DOI：
10.1186/1744-8069-10-61
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发表时间：
2014-09-21
期刊：
影响因子：
3.3
通讯作者：
Mizunuma H
中科院分区：
文献类型：
--
作者：
Matsumura Y;Yokoyama Y;Hirakawa H;Shigeto T;Futagami M;Mizunuma H
本研究旨在评估 goshajinkigan (GJG) 对紫杉醇 (PTX) 诱导的神经病变的预防作用并阐明其作用机制。 PTX 组的疼痛阈值出现时间依赖性不可逆转的下降。在PTX/GJG组中，疼痛阈值的变化与对照组相同。电镜观察显示，对照组和PTX/GJG组神经节细胞正常，但PTX组细胞核变性，线粒体肿胀。 PTX组瞬时受体电位香草酸4（TRPV4）基因的表达较对照组和PTX/GJG组显着升高。在 TRPV4 敲除小鼠中，没有观察到 PTX 诱导的痛觉过敏，并且 3 组之间的疼痛阈值没有显着差异。这些结果表明，PTX 通过增强 TRPV4 表达来诱导痛觉过敏，并表明 GJG 可能通过防止神经节细胞变性和抑制 TRPV4 表达来减轻痛觉过敏。
This study aimed to evaluate the prophylactic effect of goshajinkigan (GJG) on paclitaxel (PTX)-induced neuropathy and to elucidate the mechanism of action. There was a time-dependent irreversible decrease in pain threshold in PTX group. In PTX/GJG group, pain threshold showed changes in the same level as control. Electron microscope showed that although the ganglion cells of control and PTX/GJG groups were normal, degeneration of the nucleus and swelling of the mitochondria were observed in PTX group. Expression of transient receptor potential vanilloid 4 (TRPV4) gene in PTX group significantly increased compared with that in control and PTX/GJG groups. In TRPV4 knock-out mice, no PTX-induced hyperalgesia was observed, and there was no significant difference in pain threshold between the 3 groups. These results showed that PTX induced hyperalgesia by enhancing TRPV4 expression, and suggested that GJG might alleviate hyperalgesia by preventing degeneration of the ganglion cells and suppressing TRPV4 expression.
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影响因子：
64.8
作者：
NOGALES, E;WOLF, SG;DOWNING, KH
通讯作者：
DOWNING, KH
影响因子：
5.5
作者：
Mizuno, A;Matsumoto, N;Suzuki, M
通讯作者：
Suzuki, M
影响因子：
4.5
作者：
Materazzi, Serena;Fusi, Camilla;Nassini, Romina
通讯作者：
Nassini, Romina
影响因子：
5.1
作者：
NIWA, Y;MIYACHI, Y
通讯作者：
MIYACHI, Y
影响因子：
2.3
作者：
Kato, Yoshinori;Tateai, Yoshikazu;Yamada, Harumi
通讯作者：
Yamada, Harumi