Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.
Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.
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DOI：
10.1038/s41593-019-0381-8
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发表时间：
2019-06
影响因子：
25
通讯作者：
Häusser M
中科院分区：
文献类型：
--
作者：
Kostadinov D;Beau M;Blanco-Pozo M;Häusser M
越来越多的证据表明小脑对认知处理有贡献，但传递这些信息的具体输入途径仍不清楚。我们探讨了浦肯野细胞的攀爬纤维输入在生成和评估有关运动动作、感觉刺激和奖励之间关联的预测中的作用。我们训练小鼠执行视觉运动整合任务以获得奖励，并在任务试验之间交错提示和随机奖励。使用双光子钙成像和 Neuropixels 探测浦肯野细胞活动的记录，我们发现攀爬纤维发出奖励期望、传递和遗漏的信号。这些信号映射到小脑微区，奖励传递激活一些微区并抑制其他微区，而奖励遗漏则激活奖励激活和奖励抑制的微区。此外，在学习过程中，对可预测奖励的反应逐渐受到抑制。我们的研究结果阐明了小脑对奖励信号传导的贡献的特定输入途径，并提供了小脑活动与预测的创建和评估之间的机制联系。
There is increasing evidence for a cerebellar contribution to cognitive processing, but the specific input pathways conveying this information remain unclear. We probed the role of climbing fiber inputs to Purkinje cells in generating and evaluating predictions about associations between motor actions, sensory stimuli and reward. We trained mice to perform a visuomotor integration task to receive a reward and interleaved cued and random rewards between task trials. Using two-photon calcium imaging and Neuropixels probe recordings of Purkinje cell activity, we show that climbing fibers signal reward expectation, delivery and omission. These signals map onto cerebellar microzones, with reward delivery activating some microzones and suppressing others, and with reward omission activating both reward-activated and reward-suppressed microzones. Moreover, responses to predictable rewards are progressively suppressed during learning. Our findings elucidate a specific input pathway for cerebellar contributions to reward signaling and provide a mechanistic link between cerebellar activity and the creation and evaluation of predictions.
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影响因子：
8.8
作者：
Burgess CP;Lak A;Steinmetz NA;Zatka-Haas P;Bai Reddy C;Jacobs EAK;Linden JF;Paton JJ;Ranson A;Schröder S;Soares S;Wells MJ;Wool LE;Harris KD;Carandini M
通讯作者：
Carandini M
影响因子：
7.7
作者：
Deverett B;Koay SA;Oostland M;Wang SS
通讯作者：
Wang SS
影响因子：
16.2
作者：
Aronov, Dmitriy;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
25
作者：
Heffley W;Song EY;Xu Z;Taylor BN;Hughes MA;McKinney A;Joshua M;Hull C
通讯作者：
Hull C
影响因子：
1.9
作者：
KAWATO, M;FURUKAWA, K;SUZUKI, R
通讯作者：
SUZUKI, R