Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life.
Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life.
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DOI：
10.1371/journal.pone.0163883
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Feldman EL
中科院分区：
文献类型：
--
作者：
Sims-Robinson C;Bakeman A;Bruno E;Jackson S;Glasser R;Murphy GG;Feldman EL
高脂饮食（HFD）是导致代谢综合征的主要因素之一，与神经退行性疾病的风险增加有关，导致胰岛素抵抗和认知障碍。目前尚不清楚这些变化是否通过饮食干预得到改善。为了研究HFD对海马胰岛素信号传导和记忆的长期影响，将C57 BL 6小鼠基于饮食分为三组之一：标准饮食（对照）、HFD或HFD 16周，然后标准饮食8周（HF 16）。HFD诱导的葡萄糖耐量和海马胰岛素信号传导障碍与短期和长期记忆缺陷同时发生。此外，这些条件得到改善，饮食干预，然而，HFD诱导的海马胰岛素受体表达的减少，饮食干预没有改变。我们的研究结果表明，记忆缺陷，由于消费的HFD在早期的年龄是可逆的。
A high-fat diet (HFD), one of the major factors contributing to metabolic syndrome, which is associated with an increased risk of neurodegenerative diseases, leads to insulin resistance and cognitive impairment. It is not known whether these alterations are improved with dietary intervention. To investigate the long-term impact of a HFD on hippocampal insulin signaling and memory, C57BL6 mice were placed into one of three groups based on the diet: a standard diet (control), a HFD, or a HFD for 16 weeks and then the standard diet for 8 weeks (HF16). HFD-induced impairments in glucose tolerance and hippocampal insulin signaling occurred concurrently with deficits in both short- and long-term memory. Furthermore, these conditions were improved with dietary intervention; however, the HFD-induced decrease in insulin receptor expression in the hippocampus was not altered with dietary intervention. Our results demonstrate that memory deficits due to the consumption of a HFD at an early age are reversible.
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影响因子：
--
作者：
Craft, Suzanne;Baker, Laura D.;Montine, Thomas J.;Minoshima, Satoshi;Watson, G. Stennis;Claxton, Amy;Arbuckle, Matthew;Callaghan, Maureen;Tsai, Elaine;Plymate, Stephen R.;Green, Pattie S.;Leverenz, James;Cross, Donna;Gerton, Brooke
通讯作者：
Gerton, Brooke
胰岛素信号障碍，脂联素和血脂异常在小鼠外周和中枢神经病中的作用。
影响因子：
4.3
作者：
Anderson NJ;King MR;Delbruck L;Jolivalt CG
通讯作者：
Jolivalt CG
影响因子：
13.5
作者：
Banks, William A.;Owen, Joshua B.;Erickson, Michelle A.
通讯作者：
Erickson, Michelle A.
影响因子：
6.1
作者：
Arnold SE;Lucki I;Brookshire BR;Carlson GC;Browne CA;Kazi H;Bang S;Choi BR;Chen Y;McMullen MF;Kim SF
通讯作者：
Kim SF
影响因子：
3.5
作者：
Clark, RE;Broadbent, NJ;Squire, LR
通讯作者：
Squire, LR