Chronic Pancreatitis and the Development of Pancreatic Cancer.
Chronic Pancreatitis and the Development of Pancreatic Cancer.
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DOI：
10.2174/1871530320666200423095700
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Mishra A
中科院分区：
文献类型：
--
作者：
Kandikattu HK;Venkateshaiah SU;Mishra A
胰腺炎是一种胰腺纤维炎症性疾病，由于消化酶的激活会损害胰腺细胞，从而促进炎症，因此可能会急性或慢性发生。慢性胰腺炎伴有胰腺持续纤维炎症，会进展为胰腺癌，这是全球癌症死亡的第四大原因。胰腺癌涉及炎症、增殖、迁移和纤维化机制的交叉作用。在这篇综述中，我们讨论了细胞因子在胰腺炎和胰腺癌炎症细胞风暴中的作用及其在 SDF1α/CXCR4、SOCS3、炎症小体和 NF-κB 信号传导激活中的作用。异常的免疫反应导致腺泡和导管细胞的病理损伤，以及胰腺星状细胞活化成肌成纤维细胞样表型。我们总结了炎症促进胰腺癌的几个方面，并包括许多抑制该过程的调节分子。
Pancreatitis is a fibro-inflammatory disorder of the pancreas that can occur acutely or chronically as a result of the activation of digestive enzymes that damage pancreatic cells, which promotes inflammation. Chronic pancreatitis with persistent fibro-inflammation of the pancreas progresses to pancreatic cancer, which is the fourth leading cause of cancer deaths across the globe. Pancreatic cancer involves cross-talk of inflammatory, proliferative, migratory, and fibrotic mechanisms. In this review, we discuss the role of cytokines in the inflammatory cell storm in pancreatitis and pancreatic cancer and their role in the activation of SDF1α/CXCR4, SOCS3, inflammasome, and NF-κB signaling. The aberrant immune reactions contribute to pathological damage of acinar and ductal cells, and the activation of pancreatic stellate cells to a myofibroblast-like phenotype. We summarize several aspects involved in the promotion of pancreatic cancer by inflammation and include a number of regulatory molecules that inhibit that process.
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DOI：
10.1084/jem.20161707
发表时间：
2017-06-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Miller G