Effect of high velocity, large amplitude stimuli on the spread of depolarization in S1 "barrel" cortex.
Effect of high velocity, large amplitude stimuli on the spread of depolarization in S1 "barrel" cortex.
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DOI：
10.3109/08990220.2011.613177
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发表时间：
2011
影响因子：
0.9
通讯作者：
Pieribone VA
中科院分区：
文献类型：
--
作者：
Davis DJ;Sachdev R;Pieribone VA
我们研究了大的，可控的胡须运动，以高速传递，在麻醉小鼠桶皮层的去极化的幅度和传播的影响。刺激速度在每秒1500至6000度之间变化，运动的程度在4 - 16度之间变化。反应的上升速率与刺激的上升速率线性相关。皮层激活的初始空间范围也与刺激的上升速率有关：即刺激开始越快，反应的上升速率越快，皮层最初激活的范围就越大。的空间范围的响应和响应的上升率不相关的偏转幅度的变化。但是，更慢，更长时间的刺激产生了关闭反应，使得最慢上升刺激的实际激活程度更大。这些结果表明，皮层激活的传播依赖于刺激功能。
We examined the effect of large, controlled whisker movements, delivered at a high speed, on the amplitude and spread of depolarization in the anesthetized mouse barrel cortex. The stimulus speed was varied between 1500 to 6000 degrees per second and the extent of movement was varied between 4–16 degrees. The rate of rise of the response was linearly related to the rate of rise of the stimulus. The initial spatial extent of cortical activation was also related to the rate of rise of the stimulus: that is the faster the stimulus onset, the faster the rate of rise of the response, the larger the extent of cortex activated initially. The spatial extent of the response and the rate of rise of the response were not correlated with changes in the deflection amplitude. But slower, longer lasting stimuli produced an Off response, making the actual extent of activation larger for the slowest rising stimuli. These results indicate that the spread of cortical activation depends on stimulus features.
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