Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy
Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy
复制标题
用于大分割前列腺放射治疗的透明质酸垫片
作者：
Neil F. Mariados;P. Orio;Z. Schiffman;Thanh John Van;A. Engelman;R. Nurani;S. Kurtzman;E. López;M. Chao;T. Boike;Alvaro A. Martinez;G. Gejerman;John Lederer;J. Sylvester;Gregory Bell;Douglas Rivera;N. Shore;K. Miller;Boris Sinayuk;M. Steinberg;D. Low;A. Kishan;M. King
关键点问题：在大分割放射治疗前，透明质酸直肠间隔如何影响急性2级或更高的胃肠道毒性反应？结果在这项纳入260例前列腺癌患者的多中心随机临床试验中，201例患者在接受大分割放射治疗前被随机分配到有或无间隔器组。与对照组的13.8%相比，椎间融合器与2.9%的2级或更高急性胃肠道毒性反应相关。研究结果提示，对于接受大分割放射治疗的患者，应考虑使用透明质酸直肠间隔器。
Key Points Question How does rectal spacing with hyaluronic acid affect acute grade 2 or higher gastrointestinal toxic effects before hypofractionated radiation therapy? Findings In this multicenter randomized clinical trial of 260 patients with prostate cancer, 201 patients were randomized to the presence or absence of the spacer before receiving hypofractionated radiation therapy. The spacer was associated with a 2.9% rate of acute grade 2 or higher gastrointestinal toxic effects compared with 13.8% for the control group. Meaning The trial results suggest that hyaluronic acid rectal spacer should be considered for patients who are receiving hypofractionated radiation therapy.
影响因子：
2.1
作者：
Skolarus TA;Dunn RL;Sanda MG;Chang P;Greenfield TK;Litwin MS;Wei JT;PROSTQA Consortium
通讯作者：
PROSTQA Consortium