Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats.
Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats.
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DOI：
10.1016/j.neurobiolaging.2013.02.019
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发表时间：
2013-08
影响因子：
4.2
通讯作者：
Thibault O
中科院分区：
文献类型：
--
作者：
Pancani T;Anderson KL;Brewer LD;Kadish I;DeMoll C;Landfield PW;Blalock EM;Porter NM;Thibault O
肥胖和2型糖尿病的患病率随着年龄的增长而增加。尽管如此，很少有研究在老年动物中同时检查这些情况，也很少有研究衡量这些情况对大脑功能的影响。使用已建立的脑老化动物模型(F344大鼠)，我们研究了高脂饮食(HFD)是否会加剧认知能力下降和海马钙依赖性后超极化(年龄依赖性钙调节失调的标志)。青年和中年动物在对照组或HFD组维持4.5个月，并测量外周代谢变量、认知功能和海马区对胰岛素的电生理反应。HFD增加了外周的脂肪堆积，尽管没有出现明显的糖尿病，也没有改变空间学习和记忆。老龄动物海马脂联素水平降低，但不受HFD的影响。然而，我们第一次表明AHP对胰岛素敏感，并且这种敏感性被HFD降低。有趣的是，尽管外周血糖调节对HFD相对不敏感，但F344大鼠的大脑似乎对HFD表现出更高的敏感性。
The prevalence of obesity and type 2 diabetes increases with age. Despite this, few studies have examined these conditions simultaneously in aged animals, and fewer studies have measured the impact of these conditions on brain function. Using an established animal model of brain aging (F344 rats), we investigated whether high fat diet (HFD) exacerbates cognitive decline and the hippocampal calcium-dependent afterhyperpolarization (a marker of age-dependent calcium dysregulation). Young and mid-aged animals were maintained on control or HFD for 4.5 months and peripheral metabolic variables, cognitive function, and electrophysiological responses to insulin in the hippocampus were measured. HFD increased lipid accumulation in the periphery, though overt diabetes did not develop, nor was spatial learning and memory altered. Hippocampal adiponectin levels were reduced in aging animals but unaffected by HFD. For the first time, however, we show that the AHP is sensitive to insulin, and that this sensitivity is reduced by HFD. Interestingly, although peripheral glucose regulation was relatively insensitive to HFD, the brain appeared to show greater sensitivity to HFD in F344 rats.
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影响因子：
1.9
作者：
GALLAGHER, M;BURWELL, RD;BURCHINAL, M
通讯作者：
BURCHINAL, M
影响因子：
3.7
作者：
Blalock EM;Phelps JT;Pancani T;Searcy JL;Anderson KL;Gant JC;Popovic J;Avdiushko MG;Cohen DA;Chen KC;Porter NM;Thibault O
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Thibault O
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Gagnon, S
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作者：
KEENAN, KP;SOPER, KA;CLARK, RL
通讯作者：
CLARK, RL
影响因子：
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作者：
Kamal, Amer;Ramakers, Geert M. J.;Biessels, Geert Jan
通讯作者：
Biessels, Geert Jan