Multiple comparisons in long-term toxicity studies.

Multiple comparisons in long-term toxicity studies.
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DOI:
10.1289/ehp.94102s133
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发表时间:
1994-01
影响因子:
10.4
通讯作者:
Hothorn L
Hothorn L
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Hothorn L

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针对毒性研究中I型和II型错误的特定制剂以及典型的单向设计对照与k个治疗/剂量组,讨论了几种多重比较程序(MCP)。这些MCP的示例包括:标准多对一MCP(Dunnett程序)、序贯拒绝修改、封闭检验程序、具有有序备择假设的多对一MCP、基于应答者和无应答者混合分布假设的程序以及用于多个终点的MCP。
Several multiple comparison procedures (MCPs) are discussed in relation to the specific formulation of type I and type II errors in toxicity studies and the typical one-way design control versus k treatment/dose groups. Examples for these MCPs are: the standard many-to-one MCP (Dunnett's procedure), sequential rejection modifications, closed testing procedures, many-to-one MCPs with an ordered alternative hypothesis, procedures based on the assumption of a mixing distribution of responders and nonresponders, and MCP's for multiple end points.
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