Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants.
Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants.
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DOI：
10.1155/2013/619523
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发表时间：
2013
影响因子：
4.6
通讯作者：
van Eeden SF
中科院分区：
文献类型：
--
作者：
Hiraiwa K;van Eeden SF
大型人群队列研究表明，暴露于颗粒物与心肺发病率和死亡率之间存在关联。吸入有毒环境颗粒和气体会影响肺的先天和适应性防御系统。肺巨噬细胞在识别和处理任何吸入的异物（如病原体或颗粒物）中起着至关重要的作用。肺泡巨噬细胞和肺上皮细胞是处理和清除肺部吸入颗粒物的主要细胞。当暴露于大气颗粒物时，它们协同产生促炎症介质。这些介质产生整合的局部（肺，主要由上皮细胞控制）和全身（骨髓和血管系统，主要由巨噬细胞控制）炎症反应。全身反应导致骨髓中白细胞释放增加和肝脏中急性期蛋白产生增加，这两种因素都会影响血管并导致现有动脉粥样硬化斑块的不稳定。本文综述了肺巨噬细胞及其在空气污染物暴露诱导的炎症反应中的作用。
Large population cohort studies have indicated an association between exposure to particulate matter and cardiopulmonary morbidity and mortality. The inhalation of toxic environmental particles and gases impacts the innate and adaptive defense systems of the lung. Lung macrophages play a critically important role in the recognition and processing of any inhaled foreign material such as pathogens or particulate matter. Alveolar macrophages and lung epithelial cells are the predominant cells that process and remove inhaled particulate matter from the lung. Cooperatively, they produce proinflammatory mediators when exposed to atmospheric particles. These mediators produce integrated local (lung, controlled predominantly by epithelial cells) and systemic (bone marrow and vascular system, controlled predominantly by macrophages) inflammatory responses. The systemic response results in an increase in the release of leukocytes from the bone marrow and an increased production of acute phase proteins from the liver, with both factors impacting blood vessels and leading to destabilization of existing atherosclerotic plaques. This review focuses on lung macrophages and their role in orchestrating the inflammatory responses induced by exposure to air pollutants.
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DOI：
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发表时间：
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影响因子：
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