The Potential of Somatic Stem Cells for Alveolar Bone Tissue Engineering
The Potential of Somatic Stem Cells for Alveolar Bone Tissue Engineering
复制标题
体干细胞在牙槽骨组织工程中的潜力
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Hideki Agata
中科院分区：
文献类型：
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作者：
H. Kagami;Hideki Agata
如果没有足够的骨量，牙种植体就不能安装，缺乏足够骨量的患者可能会有很差的种植预后。此外，人们对牙种植体的美容修复的需求也在不断增加。因此，在许多情况下，骨再生是必需的，不仅是为了成功地种植牙，而且是出于美学和修复的原因。然而，骨再生并不是一个容易进行的过程。自体骨移植需要一个健康的供骨部位，而骨收集可能会导致供骨部位的并发症。人工骨替代物可以用于相对较小的缺陷。然而，应用有限，人工材料并不被普遍接受为完全替代自体骨移植。因此，需要更少的侵入性和更有效的骨再生方法。组织工程学是一门用于修复丢失或受损组织的新学科。在大多数情况下，培养的细胞、可生物降解的支架材料和/或生物活性分子被用来帮助自然存在的再生能力。自从在骨髓中发现成骨细胞以来，骨组织工程的潜力得到了积极的探索。在牙槽骨组织工程方面，近期已有基础研究和临床研究相继问世。虽然临床研究看起来很有希望，但它们也突出了一些问题，例如躯体干细胞/祖细胞的不稳定性质和个体差异。目前正在进行研究，以克服这些缺点，目标是在不久的将来将其确立为一种新的治疗选择。
Dental implants cannot be installed without sufficient bone and patients lacking adequate bone volume may have a poor prognosis for implantation. Furthermore, there is increasing demand for esthetic restoration in dental implants. Accordingly, bone regeneration is required in many cases, not only for successful dental implant installation but also for esthetic and prosthetic reasons. However, bone regeneration is not an easy procedure to perform. Autologous bone grafts require a healthy donor site, and bone collection may cause donor site morbidity. Artificial bone substitutes can be used for relatively smaller defects. However, the application is limited and artificial materials are not generally accepted as a complete replacement for an autologous bone graft. Accordingly, less invasive and more efficient methods for bone regeneration are required. Tissue engineering is a new discipline for the restoration of lost or damaged tissue. In most cases, cultured cells, biodegradable scaffold materials and/or bioactive molecules have been used to aid naturally existing regenerating ability. The potential of bone tissue engineering has been actively explored since the discovery of osteogenic cells in bone marrow. In terms of alveolar bone tissue engineering, both basic research and clinical studies have been published recently. While clinical studies seem promising, they also highlight some problems, such as the unstable nature of somatic stem/progenitor cells and individual variation. Current studies are being performed to overcome those shortcomings, aiming to establish it as a novel treatment option in the near future.
影响因子：
14
作者：
Reilly, Gwendolen C.;Radin, Shula;Ducheyne, Paul
通讯作者：
Ducheyne, Paul