Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.
Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.
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DOI：
10.1016/j.immuni.2012.09.018
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发表时间：
2013-01-24
期刊：
影响因子：
32.4
通讯作者：
Reinecker HC
中科院分区：
文献类型：
--
作者：
Chang SY;Song JH;Guleng B;Cotoner CA;Arihiro S;Zhao Y;Chiang HS;O'Keeffe M;Liao G;Karp CL;Kweon MN;Sharpe AH;Bhan A;Terhorst C;Reinecker HC
循环抗原通过固有层中的有孔毛细血管穿过小肠，然后进入引流管。但这一过程是否或如何控制粘膜免疫反应仍不清楚。在这里，我们证明了固有层的树突状细胞（DC）可以采样和处理循环和管腔抗原。令人惊讶的是，常驻CX 3CR 1 + DC的抗原交叉呈递诱导前体细胞分化为表达白细胞介素-10（IL-10）、IL-13和IL-9的CD 8 + T细胞，并且可以迁移到相邻区室中。我们得出结论，固有层CX 3CR 1 + DC促进循环抗原的监视，并作为一个管道处理自身和消化道吸收的抗原，导致诱导的CD 8 + T细胞，参与控制粘膜免疫反应过程中的T细胞活化。
Circulatory antigens transit through the small intestine via the fenestrated capillaries in the lamina propria prior to entering into the draining lymphatics. But whether or how this process controls mucosal immune responses remains unknown. Here we demonstrate that dendritic cells (DCs) of the lamina propria can sample and process both circulatory and luminal antigens. Surprisingly, antigen cross-presentation by resident CX3CR1+ DCs induced differentiation of precursor cells into CD8+ T cells that expressed interleukin-10 (IL-10), IL-13 and IL-9 and could migrate into adjacent compartments. We conclude that lamina propria CX3CR1+ DCs facilitate the surveillance of circulatory antigens and act as a conduit for the processing of self- and intestinally-absorbed-antigens, leading to the induction of CD8+ T cells, that partake in the control of T cell activation during mucosal immune responses.
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