FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors.
FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors.
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DOI：
10.1002/dvdy.21778
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发表时间：
2009-02
影响因子：
2.5
通讯作者：
Wang, Fen
中科院分区：
文献类型：
--
作者：
Lin, Yongshun;Cheng, Yi-Shing Lisa;Qin, Chunlin;Lin, Chunhong;D'Souza, Rena;Wang, Fen
来自颈环干细胞龛的牙齿上皮细胞的持续供应使小鼠门牙能够在一生中持续生长。成纤维细胞生长因子10（FGF10）已被证明是必不可少的小鼠切牙的发展和维护切牙颈环在产前发展。由于Fgfr2IIIb消融导致新生儿死亡，因此其在牙上皮中的同源受体FGFR2IIIB是否是出生后牙齿发育所需的仍然是未知的。在这里，我们报告说，组织特异性消融Fgfr 2在牙上皮导致有缺陷的上颌切牙，缺乏成釉细胞和釉质，并有发育不良的成牙本质细胞。Fgfr 2缺失上颌切牙的颈袢虽然最初形成，但未能继续发育，并在出生后不久逐渐消失。结果表明，FGFR2信号轴在维持门牙发育和终生生长所需的干细胞生态位方面发挥着作用。
Constant supplies of dental epithelial cells from stem cell niches in the cervical loop enable mouse incisors to grow continuously through life. Fibroblast growth factor 10 (FGF10) has been shown to be essential for development of mouse incisors and maintenance of incisor cervical loops during prenatal development. Whether its cognate receptor, FGFR2IIIB, in the dental epithelium is required for postnatal tooth development remains unknown since Fgfr2IIIb ablation causes neonatal lethality. Here we report that tissue-specific ablation of Fgfr2 in the dental epithelium led to defective maxillary incisors that lacked ameloblasts and the enamel, and had poorly developed odontoblasts. Although the cervical loop in Fgfr2 null maxillary incisors was formed initially, it failed to continue to develop and gradually diminished soon after birth. The results suggest that the FGFR2 signaling axis plays a role in maintaining the stem cell niche required for incisor development and lifelong growth.
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