Plasma Vitamins E and A Inversely Correlated to Mortality from Ischemic Heart Disease in Cross‐Cultural Epidemiology
Plasma Vitamins E and A Inversely Correlated to Mortality from Ischemic Heart Disease in Cross‐Cultural Epidemiology
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跨文化流行病学中血浆维生素 E 和 A 与缺血性心脏病死亡率呈负相关
DOI：
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发表时间：
1989
影响因子：
5.2
通讯作者：
P. Puska
中科院分区：
文献类型：
--
作者：
K. Gey;P. Puska
在8个研究人群中，总血浆胆固醇的中位数没有显著差异（平均5.8 mM，p> 0.05），因此与IHD死亡率无关（r2 = 0.05），维生素E（α-生育酚）绝对血浆水平的中位数与IHD死亡率呈负相关（r2 = 0.55; p = 0.003）。维生素A表现相似（r2 = 0.51; p = 0.046）。维生素E和维生素A的绝对水平与胆固醇一起预测（多元回归分析）这八个人群的IHD死亡率相当不错（r2 = 0.81; p = 0.06）。考虑到迄今为止分析的所有12个研究人群，血浆总胆固醇与IHD死亡率直接相关，正如预期的那样（r ~ 2 = 0.51; p <0.01），但血浆α-生育酚的中位数分别标准化为胆固醇和甘油三酯（分别为220 mg/dL + 110 mg/dL）与IHD死亡率保持强负相关（r2 = 0.49; p = 0.01）。在偏回归分析中，脂质标准化维生素E与IHD死亡率呈更强的负相关（r2 = 0.69; p <0.001）。同样，维生素A的表现与维生素E相似，也就是说，在个体的脂质标准化之后（r2 = 0.33; p = 0.07），以及在胆固醇独立的偏回归分析中（r2 = 0.74; p小于0.001）。这两种维生素可能单独起作用，因为在脂质标准化后，它们在个体中实际上是独立变化的（rs = 0.012）。通过多元偏回归得到的维生素E和A的组合在很大程度上预测了IHD的实际死亡率（r2 = 0.89; p小于0.001），而三变量预测模型，总胆固醇和单独脂质标准化维生素E和A的中位数，几乎完全符合这12个人群的实际IHD死亡率（r2 = 0.94; p小于0.001）。总之，维生素E和A的血浆状态是重要的，迄今为止被低估的IHD的危险因素，这可能会独立地发挥作用，但如果结合起来，可以预测至少53%的IHD死亡率的跨文化差异。将总胆固醇纳入多变量模型后，可预测高达94%的IHD死亡率。目前的流行病学数据与这一假设一致，即这些维生素分别在保护脂蛋白免受过氧化和致动脉粥样硬化的载脂蛋白B修饰方面具有生理功能，但这并不排除维生素E和A在动脉壁中的额外有益作用。
In eight study populations in which the medians of total plasma cholesterol did not differ significantly (mean 5.8 mM, p greater than 0.05) and therefore did not correlate with the IHD mortality (r2 = 0.05), the median of absolute plasma level of vitamin E (alpha-tocopherol) was inversely related to the IHD mortality (r2 = 0.55; p = 0.003). Vitamin A behaved similarly (r2 = 0.51; p = 0.046). The absolute levels of vitamins E and A together with cholesterol predicted (by multiple regression analysis) the IHD mortality of these eight populations fairly well (r2 = 0.81; p = 0.06). Considering all 12 study populations analyzed thus far, total plasma cholesterol correlated with the IHD mortality directly as expected (r2 = 0.51; p less than 0.01), but the median of the plasma alpha-tocopherol individually standardized for cholesterol and triglycerides (220 mg/dL + 110 mg/dL, respectively) maintained a strong inverse association with the IHD mortality (r2 = 0.49; p = 0.01). In the partial regression analysis, lipid-standardized vitamin E exhibited an even stronger inverse correlation with IHD mortality (r2 = 0.69; p less than 0.001). Again, vitamin A behaved similarly to vitamin E, that is, after lipid-standardization of individuals (r2 = 0.33; p = 0.07), as well as in the cholesterol-independent partial regression analysis (r2 = 0.74; p less than 0.001). Both vitamins may act singularly, for after lipid-standardization they vary de facto independently (rs = 0.012) in individuals. The combination of vitamins E and A as obtained by multiple partial regression predicted the actual IHD mortality to a large extent (r2 = 0.89; p less than 0.001), whereas the three-variable prediction model, with the median of total cholesterol and of individually lipid-standardized vitamins E and A, fit the actual IHD mortality of these 12 populations almost completely (r2 = 0.94; p less than 0.001). In conclusion, the plasma status of vitamins E and A are important, hitherto underrated risk factors of IHD, which may act independently, but can, if combined, predict at least 53% of the cross-cultural differences of IHD mortality. After inclusion of total cholesterol into a multivariate model, up to 94% of the IHD mortality can be predicted. The present epidemiological data are in agreement with the hypothesis that these vitamins have physiological functions in the protection of lipoproteins against peroxidation and atherogenic apo-B modifications, respectively, but that does not exclude additional beneficial effects of vitamin E and A in the arterial wall.
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影响因子：
15.9
作者：
PARTHASARATHY, S;YOUNG, SG;STEINBERG, D
通讯作者：
STEINBERG, D
DOI：
10.1073/pnas.81.12.3883
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
STEINBRECHER, UP;PARTHASARATHY, S;STEINBERG, D
通讯作者：
STEINBERG, D
脂蛋白改变在动脉粥样硬化发病机制中的作用。
影响因子：
4.8
作者：
Haberland,ME;Fogelman,AM
通讯作者：
Fogelman,AM
影响因子：
56.9
作者：
HABERLAND, ME;FONG, D;CHENG, L
通讯作者：
CHENG, L
维生素 A 和类胡萝卜素的血清水平可反映营养状况。
DOI：
--
发表时间：
1984
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Olson,JA
通讯作者：
Olson,JA