The universal stem cell.
The universal stem cell.
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DOI：
10.1038/s41375-022-01715-w
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发表时间：
2022-12
期刊：
影响因子：
11.4
通讯作者：
Dooner, Mark S.
中科院分区：
文献类型：
--
作者：
Quesenberry, Peter J.;Wen, Sicheng;Goldberg, Laura R.;Dooner, Mark S.
目前的教条是存在一种造血多能干细胞，驻留在骨髓中，它处于静止状态，但具有巨大的增殖和分化潜力。此外，造血系统本质上是分层的，从多能干细胞逐步分化为不同类别的造血细胞。然而，这里总结的结果表明骨髓多能造血干细胞正在活跃地循环，因此不断改变表型。随着细胞周期分化的进行，电位发生变化，如 B220 和 GR-1 表位表面表达的连续变化所示。进一步的数据表明，纯化的造血干细胞的潜力可以扩展到多种其他非造血细胞。骨髓干细胞似乎会在细胞周期的某些点产生上皮肺细胞。因此，骨髓“造血”干细胞似乎也是其他非造血组织的干细胞。这些观察结果提出了通用干细胞的概念。骨髓干细胞不仅限于造血，其分化潜能随着细胞周期的变化而不断变化。因此，骨髓中存在一种通用干细胞，随着细胞周期的进展，它会改变其分化潜力。当它存在于与其分化潜能相容的组织中、在细胞周期转变的特定点或当它与来自该组织的囊泡相互作用时，这种潜能就会被表达。
Current dogma is that there exists a hematopoietic pluripotent stem cell, resident in the marrow, which is quiescent, but with tremendous proliferative and differentiative potential. Furthermore, the hematopoietic system is essentially hierarchical with progressive differentiation from the pluripotent stem cells to different classes of hematopoietic cells. However, results summarized here indicate that the marrow pluripotent hematopoietic stem cell is actively cycling and thus continually changing phenotype. As it progresses through cell cycle differentiation potential changes as illustrated by sequential changes in surface expression of B220 and GR-1 epitopes. Further data indicated that the potential of purified hematopoietic stem cells extends to multiple other non-hematopoietic cells. It appears that marrow stem cells will give rise to epithelial pulmonary cells at certain points in cell cycle. Thus, it appears that the marrow “hematopoietic” stem cell is also a stem cell for other non-hematopoietic tissues. These observations give rise to the concept of a universal stem cell. The marrow stem cell is not limited to hematopoiesis and its differentiation potential continually changes as it transits cell cycle. Thus, there is a universal stem cell in the marrow which alters its differentiation potential as it progresses through cell cycle. This potential is expressed when it resides in tissues compatible with its differentiation potential, at a particular point in cell cycle transit, or when it interacts with vesicles from that tissue.
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影响因子：
20.3
作者：
Abkowitz, JL;Golinelli, D;Guttorp, P
通讯作者：
Guttorp, P
DOI：
10.1111/j.1749-6632.2012.06576.x
发表时间：
2012-01-01
期刊：
HEMATOPOIETIC STEM CELLS VIII
影响因子：
--
作者：
Arai, Fumio;Hosokawa, Kentaro;Suda, Toshio
通讯作者：
Suda, Toshio
DOI：
10.1089/152581602321080574
发表时间：
2002-12-01
期刊：
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
影响因子：
--
作者：
Cerny, J;Dooner, M;Quesenberry, P
通讯作者：
Quesenberry, P
影响因子：
2.6
作者：
Aliotta, JM;Keaney, P;Quesenberry, PJ
通讯作者：
Quesenberry, PJ
DOI：
10.1038/icb.1966.28
发表时间：
1966-01-01
期刊：
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE
影响因子：
--
作者：
BRADLEY, TR;METCALF, D
通讯作者：
METCALF, D