Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013.
Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013.
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DOI：
10.1002/art.39323
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发表时间：
2016-01
影响因子：
13.3
通讯作者：
Matteson, Eric L.
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文献类型：
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作者：
Krause, Megan L.;Crowson, Cynthia S.;Michet, C. John;Mason, Thomas;Muskardin, Theresa Wampler;Matteson, Eric L.
评估1994-2013年明尼苏达州奥姆斯特德县青少年特发性关节炎（JIA）的发病率和患病率以及1960-2013年青少年类风湿关节炎（JRA）的发病趋势。1994-2013年的关节炎病例通过诊断代码识别，并查阅病历，分别确诊JIA和JRA。总体发病率的95%置信区间（95% ci）是根据2010年美国白人人群的年龄和性别调整的。将其与来自同一人群的早期（1960-1993）队列进行比较。1994-2013年共发现71例JIA，经年龄和性别调整后的总发病率为10.3 / 10万（95% CI 7.9-12.7）。42例（59%）为女性，发病率为12.4 / 10万（95% CI 8.6-16.2），而男性为8.3 / 10万（95% CI 5.2-11.3）。最常见的亚型是寡关节炎（63%）。诊断时的平均±SD年龄为8.2±5.3岁。2000年1月1日和2010年1月1日JIA的患病率分别为51.0 / 10万（95% CI 25.2-76.8）和57.6 / 10万（95% CI 31.0-94.5）。对比1960 - 2013年JRA的年发病率，总体发病率无显著变化；而女性发病率下降（P = 0.003）。观察到发病率呈周期性模式，大约每10年出现一次高峰。与发病率方面的发现相似，患病率总体上没有变化，但在女性中有所下降（P = 0.048）。1960-2013年诊断的JRA患者队列中有4例死亡；标准化死亡率为1.50 （95% CI 0.41-3.83）。在过去的53年里，明尼苏达州奥姆斯特德县青少年关节炎的总体发病率没有显著变化。注意到一个一致的循环模式。
To evaluate the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Olmsted County, Minnesota in 1994–2013 and trends in juvenile rheumatoid arthritis (JRA) in 1960–2013. Cases of arthritis in 1994–2013 were identified by diagnosis code with medical chart review to confirm diagnosis separately for JIA and JRA. Overall incidence rates with 95% confidence intervals (95% CIs) were age and sex adjusted to the 2010 US white population. Comparisons were made with an earlier (1960–1993) cohort from this same population. Seventy-one incident cases of JIA in 1994–2013 were identified, with an overall age- and sex-adjusted incidence rate of 10.3 per 100,000 (95% CI 7.9–12.7). Forty-two (59%) were female, with an incidence of 12.4 per 100,000 (95% CI 8.6–16.2), as compared to 8.3 per 100,000 (95% CI 5.2–11.3) in males. The most common subtype was oligoarthritis (63%). The mean ± SD age at diagnosis was 8.2 ± 5.3 years. The prevalence of JIA on January 1, 2000 and January 1, 2010 was 51.0 per 100,000 (95% CI 25.2–76.8) and 57.6 per 100,000 (95% CI 31.0–94.5), respectively. When the annual incidence of JRA was compared over time from 1960 to 2013, there was no significant change in incidence overall; however, the incidence decreased among females (P = 0.003). A cyclic pattern of incidence was observed, with peaks approximately every 10 years. Similar to the findings with regard to incidence, prevalence did not change overall, but decreased among females (P = 0.048). There were 4 deaths in the cohort of JRA patients diagnosed in 1960–2013; the standardized mortality ratio was 1.50 (95% CI 0.41–3.83). Incidence of juvenile arthritis overall in Olmsted County, Minnesota has not changed significantly in the past 53 years. A consistent cyclic pattern was noted.
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