Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955-2007.

Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955-2007.
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DOI:
10.1002/art.27425
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发表时间:
2010-06
影响因子:
--
通讯作者:
Gabriel, Sherine E.
Gabriel, Sherine E.
中科院分区:
其他
文献类型:
--
作者:
Myasoedova, Elena;Crowson, Cynthia S.;Kremers, Hilal Maradit;Therneau, Terry M.;Gabriel, Sherine E.

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研究1995 - 2007年类风湿关节炎(RA)的发病率和流行趋势。为了增加我们先前存在的RA患者初始队列(1955-1994),我们收集了一个以人群为基础的发病率队列,年龄≥18岁,在1995年1月1日至2007年12月31日期间首次满足ACR 1987标准的RA患者,以及2005年1月1日的流行RA患者队列。对2000名美国白人的发病率和患病率进行了估计,并对其进行了年龄和性别调整。使用泊松回归方法检查发病率的趋势。1995-2007年的发病率队列包括466例患者(平均年龄55.6岁,66%为女性,69%为类风湿因子阳性)。经年龄和性别调整的RA年总发病率为40.9/10万人。经年龄调整后,女性发病率为53.1/10万人(男性为27.7/10万人)。1995-2007年期间,女性RA发病率有中度增加(p=0.02),而男性RA发病率没有增加(p=0.74)。这一增长在所有年龄组中都是相似的。2005年1月1日,经年龄和性别调整后的总患病率为0.72% (95% CI 0.66-0.77),高于1995年的0.62% (95% CI 0.55-0.69) (p<0.001)。将2005年1月1日的患病率应用于2005年美国人口,估计有150万美国成年人患有类风湿性关节炎。这比之前报道的130万有所增加。1995-2007年期间,女性类风湿性关节炎的发病率呈上升趋势。最近发病率增加的原因尚不清楚,但环境因素可能起作用。RA患病率也相应增加。
To examine the trends in incidence and prevalence of rheumatoid arthritis (RA) from 1995 to 2007. To augment our preexisting inception cohort of RA patients (1955-1994), we assembled a population-based incidence cohort of individuals aged ≥18 years who first fulfilled ACR 1987 criteria for RA between 1/1/1995 and 12/31/2007 and a cohort of patients with prevalent RA on 1/1/2005. Incidence and prevalence rates were estimated and were age- and sex-adjusted to the 2000 US whites. Trends in incidence rates were examined using Poisson regression methods. The 1995-2007 incidence cohort comprised 466 patients (mean age 55.6 years; 66% female; 69% rheumatoid factor positive). The overall age- and sex-adjusted annual RA incidence was 40.9/100,000 population. The age-adjusted incidence in women was 53.1/100,000 population,(in men: 27.7/100,000 population). During 1995-2007 there was a moderate increase in RA incidence in women (p=0.02), but not in men (p=0.74). The increase was similar among all age groups. The overall age- and sex-adjusted prevalence on 1/1/2005 was 0.72% (95% CI 0.66–0.77) up from 0.62% (95% CI 0.55–0.69) in 1995 (p<0.001). Applying the 1/1/2005 prevalence to the US 2005 population, an estimated 1.5 million US adults are affected by RA. This is up from the 1.3 million reported previously. The incidence of RA appears to be rising in women during 1995-2007 period. The reasons for this recent increase in incidence are unknown, but environmental factors may play a role. A corresponding increase in prevalence of RA was also found.
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发表时间: 2002-03-01
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