Chronic alcohol consumption enhances iNKT cell maturation and activation.
Chronic alcohol consumption enhances iNKT cell maturation and activation.
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DOI：
10.1016/j.taap.2014.11.013
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发表时间：
2015-01-15
影响因子：
3.8
通讯作者：
Meadows, Gary G.
中科院分区：
文献类型：
--
作者：
Zhang, Hui;Zhang, Faya;Zhu, Zhaohui;Luong, Dung;Meadows, Gary G.
饮酒对不同类型的免疫细胞有不同的影响。NKT细胞是一种独特的T细胞群，在不同类型的免疫反应中发挥重要的免疫调节作用。长期饮酒对NKT细胞的影响仍有待阐明。使用慢性酒精消耗的小鼠模型，我们发现酒精增加了NKT细胞的百分比，特别是胸腺和肝脏中的iNKT细胞，但在脾脏或血液中没有。饮酒降低了所有组织和器官中iNKT细胞总数中NK1.1−iNKT细胞的百分比。在胸腺中，酒精摄入增加了NK1.1+CD44hi成熟iNKT细胞的数量，但不改变NK1.1 -未成熟iNKT细胞的数量。BrdU掺入实验显示，饮酒可增加胸腺NK1.1−iNKT细胞的增殖，尤其是NK1.1−CD44lo I期iNKT细胞。NKG2A+ iNKT细胞在所有组织和器官中的百分比均增加；而CXCR3+ iNKT细胞仅在饮酒小鼠胸腺中增加。长期饮酒会增加体内α-半乳糖神经酰胺（αGalCer）刺激后产生IFN-γ的iNKT细胞的百分比，并增加血液中IFN-γ和IL-12的浓度。与增加的细胞因子产生一致，iNKT细胞的体内活化也增强了饮酒小鼠树突状细胞（DC）和NK、B和T细胞的活化。综上所述，这些数据表明，长期饮酒会增强iNKT细胞的成熟和激活，这有利于Th1免疫反应。
Alcohol consumption exhibits diverse effects on different types of immune cells. NKT cells are a unique T cell population and play important immunoregulatory roles in different types of immune responses. The effects of chronic alcohol consumption on NKT cells remain to be elucidated. Using a mouse model of chronic alcohol consumption, we found that alcohol increases the percentage of NKT cells, especially iNKT cells in the thymus and liver, but not in the spleen or blood. Alcohol consumption decreases the percentage of NK1.1− iNKT cells in the total iNKT cell population in all of the tissues and organs examined. In the thymus, alcohol consumption increases the number of NK1.1+CD44hi mature iNKT cells, but does not alter the number of NK1.1− immature iNKT cells. A BrdU incorporation assay shows that alcohol consumption increases the proliferation of thymic NK1.1− iNKT cells, especially the NK1.1− CD44lo stage I iNKT cells. The percentage of NKG2A+ iNKT cells increases in all of the tissues and organs examined; whereas, CXCR3+ iNKT cells only increases in the thymus of alcohol-consuming mice. Chronic alcohol consumption increases the percentage of IFN-γ-producing iNKT cells and increases the blood concentration of IFN-γ and IL-12 after in vivo α-galactosylceramide (αGalCer) stimulation. Consistent with the increased cytokine production, in vivo activation of iNKT cells also enhances the activation of dendritic cells (DC) and NK, B and T cells in the alcohol-consuming mice. Taken together the data indicate that chronic alcohol consumption enhances iNKT cell maturation and activation, which favors the Th1 immune response.
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DOI：
10.1084/jem.185.4.795
发表时间：
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期刊：
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影响因子：
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