Exploring the Links between Nucleotide Signaling and Quorum Sensing Pathways in Regulating Bacterial Virulence.
Exploring the Links between Nucleotide Signaling and Quorum Sensing Pathways in Regulating Bacterial Virulence.
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DOI：
10.1021/acsinfecdis.8b00255
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发表时间：
2018-12-14
影响因子：
5.3
通讯作者：
Weinert EE
中科院分区：
文献类型：
--
作者：
Fontaine BM;Duggal Y;Weinert EE
所有生物体的生存取决于对相关环境刺激的感知后适当的表型反应的实施。感觉输入通过由不同信号分子（包括气体、金属阳离子、脂质、肽和核苷酸）介导的互连的生物化学和/或电级联来传播。这些网络通常包含第二信使信号传导系统，其中配体（初级信使）结合细胞外受体，从而改变第二信使分子的细胞内浓度，所述第二信使分子最终通过与各种效应物的相互作用来调节基因表达。这些信号通路的交叉点的识别，如核苷酸第二信使和群体感应，提供了新的见解细菌使用多种输入来调节细胞代谢和表型的机制。进一步研究细菌信号通路之间的重叠可能会产生新的目标和方法来控制细菌的行为，如生物膜的形成和毒力。
The survival of all organisms depends on implementation of appropriate phenotypic responses upon perception of relevant environmental stimuli. Sensory inputs are propagated via interconnected biochemical and/or electrical cascades mediated by diverse signaling molecules, including gases, metal cations, lipids, peptides, and nucleotides. These networks often comprise second messenger signaling systems in which a ligand (the primary messenger) binds an extracellular receptor, thereby altering the intracellular concentration of a second messenger molecule which ultimately modulates gene expression through interaction with various effectors. The identification of intersections of these signaling pathways, such as nucleotide second messengers and quorum sensing, provides new insights into the mechanisms by which bacteria use multiple inputs to regulate cellular metabolism and phenotypes. Further investigations of the overlap between bacterial signaling pathways may yield new targets and methods to control bacterial behavior, such as biofilm formation and virulence.
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影响因子：
3.2
作者：
Ababneh, Qutaiba O.;Herman, Jennifer K.
通讯作者：
Herman, Jennifer K.
影响因子：
--
作者：
Diggle, Stephen P.;Matthijs, Sandra;Williams, Paul
通讯作者：
Williams, Paul
影响因子：
11
作者：
Boon, Calvin;Deng, Yinyue;Zhang, Lian-Hui
通讯作者：
Zhang, Lian-Hui
DOI：
10.1073/pnas.1205037109
发表时间：
2012-09-18
影响因子：
11.1
作者：
Deng, Yinyue;Schmid, Nadine;Zhang, Lian-Hui
通讯作者：
Zhang, Lian-Hui
影响因子：
5.4
作者：
Despotovic, Dragana;Brandis, Alexander;Tawfik, Dan S.
通讯作者：
Tawfik, Dan S.